KDM5C anticorps (full length)

N° du produit ABIN7878545

Cet anticorps Souris Monoclonal détecte spécifiquement KDM5C dans FACS. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour KDM5C anticorps (full length) (ABIN7878545)

Antigène: KDM5C (Lysine (K)-Specific Demethylase 5C (KDM5C))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp KDM5C est non-conjugé

Application: Flow Cytometry (FACS)

Clone: PCRP-KDM5C-1A11

Détail du produit anti-KDM5C anticorps

Épitope: full length

Fonction: JARID1C Antibody / KDM5C / SMCX

Purification: Protein A/G affinity

Immunogène: Recombinant full-length human protein was used as the immunogen for the JARID1C antibody.

Isotype: IgG2c

Information d'application

Indications d'application: Optimal dilution of the JARID1C antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the JARID1C antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur KDM5C

Antigène: KDM5C (Lysine (K)-Specific Demethylase 5C (KDM5C))

Autre désignation: JARID1C

Sujet: SmcX, also known as JARID1C (jumonji, AT rich interactive domain 1C), MRXJ, KDM5C or XE169, is a nuclear protein that contains one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers and belongs to the JARID1 histone demethylase family. Expressed ubiquitously with highest expression in brain and skeletal muscle, SmcX functions as a histone demethylase that removes methyl groups from lysine residues on Histone H3, thereby playing a role in the histone code, as well as transcriptional regulation and chromatin remodeling. SmcX binds iron and a-ketoglutarate as cofactors and can recruit histone deacetylases to neuron silencer elements, thus repressing the transcription of neuronal genes. Defects in the gene encoding SmcX are associated with X-linked mental retardation (XLMR), a condition characterized by cognitive impairment and a low IQ. Multiple isoforms of SmcX are expressed due to alternative splicing events.

UniProt: P41229

Pathways: L'effet Warburg