MXI1 anticorps (full length)

N° du produit ABIN7878587

Cet anticorps Souris Monoclonal détecte spécifiquement MXI1 dans WB, IF et FACS. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour MXI1 anticorps (full length) (ABIN7878587)

Antigène: MXI1 (MAX Interactor 1 (MXI1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MXI1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Clone: PCRP-MXI1-1A3

Détail du produit anti-MXI1 anticorps

Épitope: full length

Fonction: MXI1 Antibody / Max-interacting protein 1 / BHLHC11

Purification: Protein A/G affinity

Immunogène: Recombinant full-length human MXI1 protein was used as the immunogen for the MXI1 antibody.

Isotype: IgG2b

Information d'application

Indications d'application: Optimal dilution of the MXI1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the MXI1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur MXI1

Antigène: MXI1 (MAX Interactor 1 (MXI1))

Autre désignation: MXI1

Sujet: It is now well established that Myc regulation of cell proliferation and differentiation involves a family of related transcription factors. One such factor, Max, is an obligate heterodimeric partner for Myc and can also form heterodimers with at least four related proteins designated Mad 1, Mxi1 (also designated Mad 2), Mad 3 and Mad 4. Like Mad 1 and Mxi1, association of Mad 3 and Mad 4 with Max results in transcriptional repression. Both Myc and the Mad proteins have short half-lives and their synthesis is tightly regulated, while Max expression is constitutive and relatively stable. Two related mammalian cDNAs have been identified and shown to encode Mad- binding proteins. Both possess sequence homology with the yeast transcription repressor Sin3 including four conserved paired amphipathic helix (PAH) domains. mSin3A and mSin3B specifically interact with the Mad proteins via their second paired amphipathic helix domain (PAH2). It has been suggested that Mad-Max heterodimers repress transcription by tethering mSin3 to DNA as corepressors.

UniProt: P50539

Pathways: Maintenance of Protein Location