MED7 anticorps (full length)

N° du produit ABIN7878597

L’anticorps anti-MED7 Monoclonal Souris est utilisé pour la détection de MED7 dans des échantillons de Humain. Il a été validé pour ELISA, FACS et IF.

Aperçu rapide pour MED7 anticorps (full length) (ABIN7878597)

Antigène: MED7 (Mediator Complex Subunit 7 (MED7))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MED7 est non-conjugé

Application: ELISA, Flow Cytometry (FACS), Immunofluorescence (IF)

Clone: PCRP-MED7-1B8

Détail du produit anti-MED7 anticorps

Épitope: full length

Fonction: MED7 Antibody

Purification: Protein A/G affinity

Immunogène: Recombinant full-length human protein was used as the immunogen for the MED7 antibody.

Isotype: IgG2b

Information d'application

Indications d'application: Optimal dilution of the MED7 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the MED7 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur MED7

Antigène: MED7 (Mediator Complex Subunit 7 (MED7))

Autre désignation: MED7

Sujet: MED7 (Mediator of RNA polymerase II transcription subunit 7), also known as HKQ, QK, QK3 or quaking, is a 341 amino acid protein that localizes to both the cytoplasm and the nucleus and contains one KH domain. Expressed in the frontal cortex of the brain, MED7 functions as an RNA-binding protein that plays an important role in myelinization and specifically binds to the RNA core sequence 5. Additionally, MED7 regulates pre-mRNA splicing, and mRNA export and is involved in protecting and promoting the stability of select mRNAs. MED7 may be methylated by PRMT1 and may also be phosphorylated at its C-terminus, an event that decreases MED7 mRNA-binding affinity. Defects or deletions in the gene encoding MED7 are associated with astrocytic tumors and may be involved in the pathogenesis of schizophrenia. Multiple isoforms of MED7 exist due to alternative splicing events.

UniProt: O43513

Pathways: Stem Cell Maintenance, Regulation of Lipid Metabolism by PPARalpha