Recombinant MSH2 anticorps (full length)

N° du produit ABIN7878624

L’anticorps anti-MSH2 Monoclonal Souris est utilisé pour la détection de MSH2 dans des échantillons de Humain, Chien et Cat. Il a été validé pour WB et IHC (p).

Aperçu rapide pour Recombinant MSH2 anticorps (full length) (ABIN7878624)

Antigène: MSH2 (Mismatch Repair Protein 2 (MSH2))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Chien, Cat

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MSH2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RMSH2-6548

Détail du produit anti-MSH2 anticorps

Épitope: full length

Fonction: Recombinant MSH2 Antibody

Purification: Protein A/G affinity

Immunogène: Recombinant full-length human MSH2 protein was used as the immunogen for the recombinant MSH2 antibody.

Isotype: IgG2a, kappa

Information d'application

Indications d'application: Optimal dilution of the recombinant MSH2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the recombinant MSH2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur MSH2

Antigène: MSH2 (Mismatch Repair Protein 2 (MSH2))

Autre désignation: MSH2

Sujet: Mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC). Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were found at high frequency in HNPCC and were shown to be associated with microsatellite instability. The demonstration that 10 to 45 % of pancreatic, gastric, breast, ovarian and small cell lung cancers also display microsatellite instability has been interpreted to suggest that DNA mismatch repair is not restricted to HNPCC tumors but is a common feature in tumor initiation or progression.

Pathways: Réparation de l'ADN, Production of Molecular Mediator of Immune Response