MBNL3 anticorps (full length)

N° du produit ABIN7878659

Cet anticorps Souris Monoclonal détecte spécifiquement MBNL3 dans FACS. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour MBNL3 anticorps (full length) (ABIN7878659)

Antigène: MBNL3 (Muscleblind-Like Splicing Regulator 3 (MBNL3))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp MBNL3 est non-conjugé

Application: Flow Cytometry (FACS)

Classe de qualité: Carrier-free

Clone: PCRP-MBNL3-1D11

Détail du produit anti-MBNL3 anticorps

Épitope: full length

Fonction: MBNL3 Antibody (azide and preservative free)

Purification: Protein A/G affinity

Immunogène: Recombinant full-length human MBNL3 protein was used as the immunogen for the MBNL3 antibody.

Isotype: IgG2b

Information d'application

Indications d'application: Optimal dilution of the MBNL3 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: -20 °C

Stockage commentaire: Aliquot the MBNL3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur MBNL3

Antigène: MBNL3 (Muscleblind-Like Splicing Regulator 3 (MBNL3))

Autre désignation: MBNL3

Sujet: Pre-mRNA splicing is a critical step in the posttranscriptional regulation of gene expression. Several protein complexes are involved in proper mRNA splicing and transport. The muscleblind proteins, MBNL1, MBNL2 and MBNL3, promote inclusion or exclusion of specific exons on different pre-mRNAs by antagonizing the activity of CUG-BP and ETR-3-like factors bound to distinct intronic sites. MBNL1 and 2, which associate with expanded CUG repeats in vitro, localize to the nuclear foci in both DM1 and DM2 (myotonic dystrophy types 1 and 2), suggesting that the nuclear accumulation of mutant RNA is pathogenic in DM1, therefore implicating MBNL1 and 2 in the pathogenesis of both disorders. MBNL3, a 354 amino acid protein, inhibits expression of muscle differentiation, opposite to the function of MBNL1, which functions as a promoter of muscle differentiation. MBNL3 shows strong expression in placenta.

UniProt: Q9NUK0

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development