ORC1 anticorps (full length)

N° du produit ABIN7878763

Cet anticorps anti-ORC1 Monoclonal Souris (Clone 7F6-1) (ABIN7878763) détecte spécifiquement ORC1 dans ELISA. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour ORC1 anticorps (full length) (ABIN7878763)

Antigène: ORC1 (ORC1L) (Origin Recognition Complex, Subunit 1 (ORC1L))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ORC1 est non-conjugé

Application: ELISA

Clone: 7F6-1

Détail du produit anti-ORC1 anticorps

Épitope: full length

Fonction: ORC1 Antibody / Origin Recognition Complex 1

Purification: Protein G affinity chromatography

Immunogène: A recombinant full-length human ORC1 protein was used as the immunogen for this ORC1 antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the ORC1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the ORC1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur ORC1

Antigène: ORC1 (ORC1L) (Origin Recognition Complex, Subunit 1 (ORC1L))

Autre désignation: ORC1

Sujet: The initiation of DNA replication is a multi-step process that depends on the formation of pre-replication complexes, which trigger initiation. Among the proteins required for establishing these complexes are the origin recognition complex (ORC) proteins. ORC proteins bind specifically to origins of replication where they serve as scaffold for the assembly of additional initiation factors. Human ORC subunits 1-6 are expressed in the nucleus of proliferating cells and tissues, such as the testis. ORC1 and ORC2 are both expressed at equivalent concentrations throughout the cell cycle, however, only ORC2 remains stably bound to chromatin. ORC4 and ORC6 are also expressed constantly throughout the cell cycle. ORC2, ORC3, ORC4 and ORC5 form a core complex upon which ORC6 and ORC1 assemble. The formation of this core complex suggests that ORC proteins play a crucial role in the G1-S transition in mammalian cells.

UniProt: Q13415

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA