PLK1 anticorps (full length)

N° du produit ABIN7878824

Cet anticorps Souris Monoclonal détecte spécifiquement PLK1 dans WB et ELISA. Il présente une réactivité avec des échantillons de Xenopus laevis.

Aperçu rapide pour PLK1 anticorps (full length) (ABIN7878824)

Antigène: PLK1 (Polo-Like Kinase 1 (PLK1))

Reactivité: Xenopus laevis

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PLK1 est non-conjugé

Application: Western Blotting (WB), ELISA

Clone: AZ44

Détail du produit anti-PLK1 anticorps

Épitope: full length

Fonction: PLK1 Antibody / Polo-Like Kinase 1

Purification: Protein G affinity chromatography

Immunogène: Recombinant Xenopus laevis full length protein was used as the immunogen for the PLK1 antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the PLK1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the PLK1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur PLK1

Antigène: PLK1 (Polo-Like Kinase 1 (PLK1))

Autre désignation: PLK1

Sujet: Plk (for polo-like kinase) encodes a serine/threonine kinase that is closely related to polo and CDC5, genes that are required for passage through mitosis in Drosophila and Saccharomyces, respectively. Polo and Cdc5 both code for proteins that are involved in regulating the function of the mitotic spindle. Plk protein accumulates in the cell during the S and G2 phases of the cell cycle, Plk protein content and catalytic activity peak at the onset of mitosis, followed by a rapid reduction after mitosis. Plk expression is detectable in mitotically active tissues such as colon and placenta, as well as in tumors of various origins. It has also been suggested that Plk may serve as a marker of cell proliferation. Required for recovery after DNA damage checkpoint and entry into mitosis. Required for kinetochore localization of BUB1B. Phosphorylates SGOL1. Required for spindle pole localization of isoform 3 of SGOL1 and plays a role in regulating its centriole cohesion function. Phosphorylates BORA, and thereby promotes the degradation of BORA. Contributes to the regulation of AURKA function. Regulates TP53 stability through phosphorylation of TOPORS. Useful for confirming that extracts have maintained CSF status and have not yet been activated into interphase.

UniProt: P70032

Pathways: Cycle Cellulaire, M Phase