PRMT6 anticorps (full length)

N° du produit ABIN7878875

Cet anticorps Souris Monoclonal détecte spécifiquement PRMT6 dans IF et FACS. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour PRMT6 anticorps (full length) (ABIN7878875)

Antigène: PRMT6 (Protein Arginine Methyltransferase 6 (PRMT6))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp PRMT6 est non-conjugé

Application: Immunofluorescence (IF), Flow Cytometry (FACS)

Clone: PCRP-PRMT6-2C9

Détail du produit anti-PRMT6 anticorps

Épitope: full length

Fonction: PRMT6 Antibody

Purification: Protein A/G affinity

Immunogène: Recombinant full-length human PRMT6 protein was used as the immunogen for the PRMT6 antibody.

Isotype: IgG2b

Information d'application

Indications d'application: Optimal dilution of the PRMT6 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the PRMT6 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur PRMT6

Antigène: PRMT6 (Protein Arginine Methyltransferase 6 (PRMT6))

Autre désignation: PRMT6

Sujet: A class of proteins termed type 1 protein arginine N-methyltransferase (PRMT) enzymes contribute to posttranslational modification of RNA-binding proteins, but differ in substrate specificities, oligomerization properties and subcellular localization. PRMTs contain an S-adenosylmethione motif which functions to add one or two methyl groups to guanidino nitrogens of arginine (R) side chains. PRMT6, also known as HRMT1L6, is a nuclear protein belonging to the PRMT family and is predominantly expressed in testis and kidney. It is known to methylate Histones H3, H4 and H2A. PRMT6 is the major dimethyltransferase for Histone H3 and specifically methylates Histone H3 at R2. Methylation at Histone H3 R2 acts to inhibit Histone H3 K4 trimethylation and ultimately leads to the transcriptional repression of genes that are activated by Histone H3 K4 trimethylation. In addition, PRMT6 methylates HIV TAT, possibly functioning as a form of cellular innate immunity to restrict levels of HIV replication.

UniProt: Q96LA8