Recombinant Retinoblastoma Protein (Rb) anticorps (full length)

N° du produit ABIN7878913

Cet anticorps anti-Retinoblastoma Protein (Rb) Monoclonal Lapin (Clone RB1-7080R) (ABIN7878913) détecte spécifiquement Retinoblastoma Protein (Rb) dans IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Recombinant Retinoblastoma Protein (Rb) anticorps (full length) (ABIN7878913)

Antigène: Retinoblastoma Protein (Rb) (Rb Protein) (Retinoblastoma Protein (Rb Protein))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp Retinoblastoma Protein (Rb) est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB1-7080R

Détail du produit anti-Retinoblastoma Protein (Rb) anticorps

Épitope: full length

Fonction: Recombinant Retinoblastoma Antibody

Purification: Protein A/G affinity

Immunogène: Recombinant human full-length protein was used as the immunogen for the recombinant Retinoblastoma antibody.

Isotype: IgG, kappa

Information d'application

Indications d'application: Optimal dilution of the recombinant Retinoblastoma antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the recombinant Retinoblastoma antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur Retinoblastoma Protein (Rb)

Antigène: Retinoblastoma Protein (Rb) (Rb Protein) (Retinoblastoma Protein (Rb Protein))

Autre désignation: Retinoblastoma

Sujet: Recognizes a 105 kDa phosphoprotein, identified as retinoblastoma (Rb) gene product. Its epitope is localized between aa 703-772. It shows no cross reaction with p107 or p130. It specifically stains the nuclei of BT-20 cells and primary human foreskin fibroblast (HFF) cells. It does not stain the Rb-negative BT549 cells. It reacts with the hyperphosphorylated as well as the un (under) phosphorylated form of the Rb protein. Retinoblastoma gene product plays a key role in cell cycle control. It has been identified as a tumor suppressor gene whose loss of its function leads to tumor development. It is widely expressed in a variety of human tissues including breast, esophageal, squamous cell and cervical carcinoma.

UniProt: P06400

Pathways: Mitotic G1-G1/S Phases