SATB1 anticorps (full length)

N° du produit ABIN7878975

L’anticorps anti-SATB1 Monoclonal Souris est utilisé pour la détection de SATB1 dans des échantillons de Humain. Il a été validé pour IHC (p).

Aperçu rapide pour SATB1 anticorps (full length) (ABIN7878975)

Antigène: SATB1 (SATB Homeobox 1 (SATB1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp SATB1 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: SATB1-2661

Détail du produit anti-SATB1 anticorps

Épitope: full length

Fonction: SATB1 Antibody / Special AT-rich sequence-binding protein 1

Purification: Protein A/G affinity

Immunogène: Recombinant full-length human SATB1 protein was used as the immunogen for the SATB1 antibody.

Isotype: IgG1

Information d'application

Indications d'application: Optimal dilution of the SATB1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the SATB1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur SATB1

Antigène: SATB1 (SATB Homeobox 1 (SATB1))

Autre désignation: SATB1

Sujet: The homeoproteins CCAAT displacement protein (CDP) and special AT-rich sequence binding protein 1 (SATB1) are transcriptional repressors of many cellular genes, and they participate in cell development and cell type differentiation. SATB1 is expressed primarily in thymocytes, and, like CDP, it also contains a distinct homeobox DNA-binding domain that is essential for DNA binding. SATB1 and CDP interact through these homeodomains and synergistically function as mediators of gene expression. SATB1 contains an additional domain that has a higher affinity for DNA and specifically facilitates the direct association between SATB1 and the nuclear matrix attachment regions (MARs) of DNA. MARs are specific DNA sequences that bind to the nuclear matrix and form the base of chromosomal loops that organize the chromosomes and regulate DNA transcription and replication within the nucleus. The association of SATB1 with the core unwinding element within the base-unpairing region of MARs requires both the MAR and homeobox binding domains of SATB1.

UniProt: Q01826

Pathways: Caspase Cascade in Apoptosis, Activated T Cell Proliferation