Spastin anticorps (full length)

N° du produit ABIN7879072

Cet anticorps anti-Spastin Monoclonal Souris (Clone Sp 3G11-1) (ABIN7879072) détecte spécifiquement Spastin dans WB, IF et IHC (p). L’anticorps est réactif avec des échantillons de Souris, Rat et Humain.

Aperçu rapide pour Spastin anticorps (full length) (ABIN7879072)

Antigène: Spastin (SPAST)

Reactivité: Souris, Rat, Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Spastin est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: Sp 3G11-1

Détail du produit anti-Spastin anticorps

Épitope: full length

Fonction: Spastin Antibody

Purification: Protein G affinity chromatography

Immunogène: Recombinant full length human Spastin protein was used as the immunogen for the Spastin antibody.

Isotype: IgG2a, kappa

Information d'application

Indications d'application: Optimal dilution of the Spastin antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the Spastin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur Spastin

Antigène: Spastin (SPAST)

Autre désignation: Spastin

Sujet: The AAA protein family members share an ATPase domain and have roles in various cellular processes including intracellular motility, membrane trafficking, proteolysis, protein folding and organelle biogenesis. Spastin, a member of the AAA protein family, is a 616 amino acid protein and is involved in the function or assembly of nuclear protein complexes. The Spastin protein is expressed ubiquitously and localizes to the nucleus and the cytoplasm, where it may also be involved in microtubule dynamics. Mutations in the Spastin gene (SPAST, SPG4) cause the most common form of spastic paraplegia 4, an autosomal dominant form of hereditary spastic paraplegia (HSP). HSPs comprise a group of inherited neurological disorders characterized by spastic lower extremity weakness due to a length-dependent, retrograde axonopathy of corticospinal motor neurons. SPAST-specific mutations account for approximately 40 % of all autosomal dominant HSPs.

Pathways: Dynamique des Microtubules, M Phase, Regulation of Cell Size