TMPRSS2 anticorps (full length)

N° du produit ABIN7879196

Cet anticorps Souris Monoclonal détecte spécifiquement TMPRSS2 dans IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour TMPRSS2 anticorps (full length) (ABIN7879196)

Antigène: TMPRSS2 (Transmembrane Protease, serine 2 (TMPRSS2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp TMPRSS2 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: TMPRSS2-7410

Détail du produit anti-TMPRSS2 anticorps

Épitope: full length

Fonction: TMPRSS2 Antibody / Transmembrane protease serine 2

Purification: Protein A/G affinity

Immunogène: Recombinant full-length human TMPRSS2 protein was used as the immunogen for the TMPRSS2 antibody.

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal dilution of the TMPRSS2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the TMPRSS2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur TMPRSS2

Antigène: TMPRSS2 (Transmembrane Protease, serine 2 (TMPRSS2))

Autre désignation: TMPRSS2

Sujet: Extracellular proteases mediate the digestion of neighboring extracellular matrix components in initial tumor growth, allow desquamation of tumor cells into the surrounding environment, provide the basis for invasion of basement membranes in targeted metastatic organs and are required for release and activation of many growth and angiogenic factors. The TMPRSS2 gene encodes a 492 amino acid multimeric serine protease, which is mainly expressed in the mouse prostate and kidney, and is also expressed in the human small intestine, prostate, colon, stomach and salivary gland. TMPRSS2 contains several domains, including a serine protease domain of the S1 family, a scavenger receptor cysteine-rich domain of group A, an LDL receptor class A domain and a transmembrane domain. TMPRSS2 is expressed as a full length form and a cleaved protease domain and its expression is increased by androgenic hormones. TMPRSS2 is also expressed in prostate carcinoma, suggesting that it may play a role in prostate carcinogenesis.

UniProt: O15393

Pathways: SARS-CoV-2 Protein Interactome