ube3a anticorps (full length)

N° du produit ABIN7879290

L’anticorps anti-ube3a Monoclonal Souris est utilisé pour la détection de ube3a dans des échantillons de Humain. Il a été validé pour IF et FACS.

Aperçu rapide pour ube3a anticorps (full length) (ABIN7879290)

Antigène: ube3a (Ubiquitin Protein Ligase E3A (ube3a))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp ube3a est non-conjugé

Application: Immunofluorescence (IF), Flow Cytometry (FACS)

Clone: PCRP-UBE3A-1A2

Détail du produit anti-ube3a anticorps

Épitope: full length

Fonction: Ubiquitin-protein ligase E3A Antibody / UBE3A

Purification: Protein A/G affinity

Immunogène: Recombinant full-length human UBE3A protein was used as the immunogen for the Ubiquitin-protein ligase E3A antibody.

Isotype: IgG1

Information d'application

Indications d'application: Optimal dilution of the Ubiquitin-protein ligase E3A antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the Ubiquitin-protein ligase E3A antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur ube3a

Antigène: ube3a (Ubiquitin Protein Ligase E3A (ube3a))

Autre désignation: Ubiquitin-protein ligase E3A

Sujet: E6-associating protein (E6-AP), also designated ubiquitin protein ligase E3A (UBE3A), is a component of the ubiquitin-mediated proteolytic pathway that selectively targets proteins for degradation by the 26S Proteasome. Ubiquitin(Ub) is directly conjugated to protein substrates by the transfer of Ub from anE2 ubiquitin conjugating enzyme to the target protein. This conjugation is facilitated by the enzymatic activity of E3 ubiquitin ligase family members such asE6-AP. Several substrates of E6-AP have been identified and include the tumor suppressor protein p53 and the mammalian homolog of Rad23, HHR23A.Previous studies have indicated that E6-AP associates with the human papilloma virus E6 oncogene, which forms a complex with p53 and there by potentiates E6-AP mediated ubiquitination of p53. Genetic mutations that impair E6-AP activity result in the accumulation of p53 in the cytoplasm, and in many instances, these mutations are associated with the development of the rare neurodevelopmental disorder Angelman syndrome (AS), which is characterized by severe motor dysfunction and mental retardation.

UniProt: Q05086

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway