GSTM2 anticorps (Middle Region)

N° du produit ABIN7879521

L’anticorps anti-GSTM2 Polyclonal Lapin est utilisé pour la détection de GSTM2 dans des échantillons de Rat et Souris. Il a été validé pour WB et IHC.

Aperçu rapide pour GSTM2 anticorps (Middle Region) (ABIN7879521)

Antigène: GSTM2 (Glutathione S-Transferase mu 2 (Muscle) (GSTM2))

Reactivité: Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp GSTM2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-GSTM2 anticorps

Épitope: Middle Region

Fonction: GSTM2 Antibody / Glutathione S-transferase Mu 2

Purification: Immunogen affinity purified

Immunogène: A synthetic peptide corresponding to a sequence in the middle region of mouse GSTM2 was used as the immunogen for the GSTM2 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the GSTM2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the GSTM2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur GSTM2

Antigène: GSTM2 (Glutathione S-Transferase mu 2 (Muscle) (GSTM2))

Autre désignation: GSTM2

Sujet: GSTM2 antibody detects Glutathione S-transferase Mu 2, a detoxification enzyme that catalyzes the conjugation of glutathione to electrophilic compounds, protecting cells from oxidative damage and xenobiotic stress. Encoded by the GSTM2 gene on chromosome 1p13.3, this enzyme belongs to the mu class of cytosolic glutathione S-transferases (GSTs) and plays a critical role in the metabolism of carcinogens, environmental toxins, and therapeutic drugs. GSTM2 is particularly abundant in liver, kidney, and lung tissues, where it contributes to phase II detoxification.

Structurally, GSTM2 forms homodimers, each monomer containing an N-terminal glutathione-binding site (G-site) and a C-terminal hydrophobic substrate-binding site (H-site). This configuration enables GSTM2 to catalyze the conjugation of reduced glutathione (GSH) to electrophilic substrates, rendering them more water-soluble for excretion. GSTM2 also exhibits peroxidase activity, neutralizing reactive oxygen species and maintaining cellular redox balance.

The GSTM2 antibody is widely used in toxicology, pharmacology, and metabolic research to study oxidative stress responses, detoxification pathways, and enzyme induction mechanisms. Western blot analysis identifies a 26 kilodalton band corresponding to GSTM2, while immunohistochemistry reveals strong cytoplasmic staining in hepatocytes and renal tubular cells. This antibody supports investigations into tissue-specific detoxification and metabolic adaptation to stress and xenobiotics.

Genetic polymorphisms in GSTM2 and related GST genes influence susceptibility to environmental toxins, carcinogens, and drug-induced injury. Reduced expression or functional loss of GSTM2 increases oxidative damage and contributes to disorders such as asthma, cancer, and neurodegenerative disease. Conversely, elevated expression is associated with chemoresistance and altered drug metabolism in tumor cells. The GSTM2 antibody provides a reliable tool for quantifying enzyme expression and understanding its contribution to cellular defense systems. NSJ Bioreagents validates this antibody for its applications, ensuring dependable performance for detoxification and redox biology research.

UniProt: P15626

Pathways: Negative Regulation of Transporter Activity