GNRHR anticorps (N-Term)

N° du produit ABIN7879608

L’anticorps anti-GNRHR Monoclonal Souris est utilisé pour la détection de GNRHR dans des échantillons de Humain. Il a été validé pour ELISA.

Aperçu rapide pour GNRHR anticorps (N-Term) (ABIN7879608)

Antigène: GNRHR (Gonadotropin-Releasing Hormone Receptor (GNRHR))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp GNRHR est non-conjugé

Application: ELISA

Clone: A9E4

Détail du produit anti-GNRHR anticorps

Épitope: N-Term

Fonction: GnRH-Receptor Antibody / LHCG Receptor

Séquence: MANSASPEQN QHCSAINNSI PLMQGNLPY

Purification: Protein A/G affinity

Immunogène: amino acids MANSASPEQNQHCSAINNSIPLMQGNLPY from the N-terminal of human GnRH receptor was used as the immunogen for the GnRH-Receptor antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the GnRH-Receptor antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the GnRH-Receptor antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur GNRHR

Antigène: GNRHR (Gonadotropin-Releasing Hormone Receptor (GNRHR))

Autre désignation: GnRH-Receptor

Sujet: Recognizes an epitope on the extracellular domain of gonadotropin releasing hormone (GnRH) receptor or luteinizing hormone receptor (LHCGR). Lutropin (also designated luteinizing hormone) plays a role in spermatogenesis and ovulation by stimulating the testes and ovaries to produce steroids. Gonadotropin (also designated choriogonadotropin) production in the placenta maintains estrogen and progesterone levels during the first trimester of pregnancy. Ovaries and testes abundantly express luteinizing hormone/choriogonadotropin receptor. GnRH receptor contains seven hydrophobic transmembrane domains connected by hydrophilic extracellular and intracellular loops characteristic of G-protein coupled receptors. GnRH stimulates the gonadotrophs of the anterior pituitary to secrete luteinizing hormone (LH) as well as follicle-stimulating hormone (FSH). GnRH influences the protective effect of pregnancy and Gonadotropin against breast cancer. The expression of GnRH on breast carcinoma correlates in part to the degree of tumor differentiation. GnRH-positive breast tumors occur more frequently in tumors with greater cell differentiation in premenopausal women. GnRH is present in luteal and granulosa cells as well as in ovarian cell membrane preparations.

UniProt: P30968