Pyruvate Kinase anticorps (N-Term)

N° du produit ABIN7879648

Cet anticorps anti-Pyruvate Kinase Monoclonal Souris (Clone 11I4C3) (ABIN7879648) détecte spécifiquement Pyruvate Kinase dans WB, IF, IHC (p) et FACS. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Pyruvate Kinase anticorps (N-Term) (ABIN7879648)

Antigène: Pyruvate Kinase (PK)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Pyruvate Kinase est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Clone: 11I4C3

Détail du produit anti-Pyruvate Kinase anticorps

Épitope: N-Term

Fonction: Pyruvate Kinase Antibody / OIP-3 / PKM2

Séquence: KDPVQEAWAE DVDLRVNFAM NVGKAR

Purification: Antigen affinity purified

Immunogène: N-terminal region amino acids KDPVQEAWAEDVDLRVNFAMNVGKAR from the human protein were used as the immunogen for the Pyruvate Kinase antibody.

Isotype: IgG2b

Information d'application

Indications d'application: Optimal dilution of the Pyruvate Kinase antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the Pyruvate Kinase antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur Pyruvate Kinase

Antigène: Pyruvate Kinase (PK)

Autre désignation: Pyruvate Kinase

Sujet: PKM (Pyruvate Kinase, Muscle), also known as OIP-3, PK3 and PKM2, is an enzyme that in humans is encoded by the PKM gene. The activity of pyruvate kinase subtype M2 is increased by fructose 1, 6-bisphosphate (Fru-1, 6-P2). By in situ hybridization, Popescu and Cheng (1990) mapped the THBP1 gene to 15q24-q25. Ashizawa et al. (1991) manipulated the intracellular Fru-1, 6-P2 concentration in several mammalian cell lines, including human, by varying the glucose concentration in the media. Using a novel proteomic screen for phosphotyrosine-binding proteins, Christofk et al. (2008) observed that PKM2 binds directly and selectively to tyrosine-phosphorylated peptides.

UniProt: P14618