RPA2 anticorps (pThr21)

N° du produit ABIN7879788

L’anticorps anti-RPA2 Monoclonal Lapin est utilisé pour la détection de RPA2 dans des échantillons de Humain. Il a été validé pour WB.

Aperçu rapide pour RPA2 anticorps (pThr21) (ABIN7879788)

Antigène: RPA2 (Replication Protein A2, 32kDa (RPA2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp RPA2 est non-conjugé

Application: Western Blotting (WB)

Clone: FCG-18

Détail du produit anti-RPA2 anticorps

Épitope: pThr21

Fonction: Phospho-RPA32 Antibody (pT21)

Purification: Affinity purified

Immunogène: A synthetic peptide specific to human RPA32 (surrounding pT21) was used as the immunogen for the phospho-RPA32 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the phospho-RPA32 antibody (pT21) should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store the phospho-RPA32 antibody (pT21) at -20oC.

Détails sur RPA2

Antigène: RPA2 (Replication Protein A2, 32kDa (RPA2))

Autre désignation: RPA32

Sujet: The RPA2 gene encodes a subunit of the heterotrimeric Replication Protein A (RPA) complex, which binds to single-stranded DNA (ssDNA), forming a nucleoprotein complex that plays an important role in DNA metabolism, being involved in DNA replication, repair, recombination, telomere maintenance, and co-ordinating the cellular response to DNA damage through activation of the ataxia telangiectasia and Rad3-related protein (ATR) kinase. The RPA complex protects single-stranded DNA from nucleases, prevents formation of secondary structures that would interfere with repair, and co-ordinates the recruitment and departure of different genome maintenance factors. The heterotrimeric complex has two different modes of ssDNA binding, a low-affinity and high-affinity mode, determined by which oligonucleotide/oligosaccharide-binding (OB) domains of the complex are utilized, and differing in the length of DNA bound. This subunit contains a single OB domain that participates in high-affinity DNA binding and also contains a winged helix domain at its carboxy terminus, which interacts with many genome maintenance protein. Post-translational modifications of the RPA complex also plays a role in co-ordinating different damage response pathways. [RefSeq]

UniProt: P15927

Pathways: Telomere Maintenance, Réparation de l'ADN, Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA