BNIP3L/NIX anticorps

N° du produit ABIN7880065

Cet anticorps anti-BNIP3L/NIX Monoclonal Lapin (Clone ABIB-2) (ABIN7880065) détecte spécifiquement BNIP3L/NIX dans WB. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour BNIP3L/NIX anticorps (ABIN7880065)

Antigène: BNIP3L/NIX (BNIP3L) (BCL2/adenovirus E1B 19kDa Interacting Protein 3-Like (BNIP3L))

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp BNIP3L/NIX est non-conjugé

Application: Western Blotting (WB)

Clone: ABIB-2

Détail du produit anti-BNIP3L/NIX anticorps

Fonction: Nix Antibody / BNIP3L

Purification: Affinity purified

Immunogène: A synthetic peptide specific to human Nix / BNIP3L was used as the immunogen for the Nix antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the Nix antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store the Nix antibody at -20oC.

Détails sur BNIP3L/NIX

Antigène: BNIP3L/NIX (BNIP3L) (BCL2/adenovirus E1B 19kDa Interacting Protein 3-Like (BNIP3L))

Autre désignation: Nix

Sujet: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like' (BNIP3L), also called NIP3-like protein X (Nix) induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor. [UniProt]

UniProt: O60238

Pathways: Autophagy