CPS1 anticorps

N° du produit ABIN7880153

Cet anticorps Souris Monoclonal détecte spécifiquement CPS1 dans IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour CPS1 anticorps (ABIN7880153)

Antigène: CPS1 (Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CPS1 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: CPS1-9865

Détail du produit anti-CPS1 anticorps

Fonction: Carbamoyl phosphate synthetase 1 Antibody / CPS1

Purification: Protein A/G affinity

Immunogène: A recombinant partial protein from human Carbamoyl phosphate synthetase 1 protein was used as the immunogen for the Carbamoyl phosphate synthetase 1 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the Carbamoyl phosphate synthetase 1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the Carbamoyl phosphate synthetase 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur CPS1

Antigène: CPS1 (Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1))

Autre désignation: Carbamoyl phosphate synthetase 1

Sujet: This MAb recognizes a protein of 165 kDa, identified as carbamoyl phosphate synthetase 1 (CPS1). This mitochondrial enzyme catalyzes synthesis of carbamoyl phosphate from ammonia and bicarbonate. This reaction is the first committed step of the urea cycle, which is important in the removal of excess urea from cells. Deficiency of CPS1 is an autosomal recessive disorder that causes hyperammonemia. CPS1 is a hepatocyte specific protein that localizes to the mitochondria of hepatocytes. It is a sensitive marker for distinguishing hepatocellular carcinomas (HCC) from other metastatic carcinomas as well as cholangio-carcinomas. HCC s occur primarily in the stomach, but they are also found in many other organs. CPS1 may also be a useful marker for intestinal metaplasia. Reportedly, strong expression of CPS1 correlates with smaller tumor size and longer patient survival. Occasionally, CPS1 is also found in gastric carcinomas as well as in a few other non-hepatic tumors.

UniProt: P31327

Pathways: Response to Growth Hormone Stimulus, Cellular Glucan Metabolic Process