CPS1 anticorps

N° du produit ABIN7880157

L’anticorps anti-CPS1 Monoclonal Souris est utilisé pour la détection de CPS1 dans des échantillons de Humain. Il a été validé pour IHC (p).

Aperçu rapide pour CPS1 anticorps (ABIN7880157)

Antigène: CPS1 (Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CPS1 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: CPS1-8420

Détail du produit anti-CPS1 anticorps

Fonction: CPS1 Antibody / Carbamoyl phosphate synthetase 1

Purification: Protein A/G affinity

Immunogène: Recombinant human CPS1 protein was used as the immunogen for the CPS1 antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the CPS1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the CPS1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur CPS1

Antigène: CPS1 (Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1))

Autre désignation: CPS1

Sujet: This mAb recognizes a protein of 165 kDa, identified as carbamoyl phosphate synthetase 1 (CPS1). This mitochondrial enzyme catalyzes synthesis of carbamoyl phosphate from ammonia and bicarbonate. This reaction is the first committed step of the urea cycle, which is important in the removal of excess urea from cells.Deficiency of CPS1 is an autosomal recessive disorder that causes hyperammonemia. CPS1 is a hepatocyte specific protein that localizes to the mitochondria of hepatocytes. It is a sensitive marker for distinguishing hepatocellular carcinomas (HCC) from other metastatic carcinomas as well as cholangio-carcinomas. HCC s occur primarily in the stomach, but they are also found in many other organs. CPS1 may also be a useful marker for intestinal metaplasia. Reportedly, strong expression of CPS1 correlates with smaller tumor size and longer patient survival. Occasionally, CPS1 is also found in gastric carcinomas as well as in a few other non-hepatic tumors.

UniProt: P31327

Pathways: Response to Growth Hormone Stimulus, Cellular Glucan Metabolic Process