CPS1 anticorps

N° du produit ABIN7880158

Cet anticorps anti-CPS1 Monoclonal Souris (Clone CPS1-8417) (ABIN7880158) détecte spécifiquement CPS1 dans IHC (p). L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour CPS1 anticorps (ABIN7880158)

Antigène: CPS1 (Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CPS1 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: CPS1-8417

Détail du produit anti-CPS1 anticorps

Fonction: CPS1 Antibody / Carbamoyl phosphate synthetase 1 (azide and preservative free)

Purification: Protein A/G affinity

Immunogène: Recombinant human CPS1 protein was used as the immunogen for the CPS1 antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the CPS1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: -20 °C

Stockage commentaire: Aliquot the CPS1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur CPS1

Antigène: CPS1 (Carbamoyl-Phosphate Synthase 1, Mitochondrial (CPS1))

Autre désignation: CPS1

Sujet: This mAb recognizes a protein of 165 kDa, identified as carbamoyl phosphate synthetase 1 (CPS1). This mitochondrial enzyme catalyzes synthesis of carbamoyl phosphate from ammonia and bicarbonate. This reaction is the first committed step of the urea cycle, which is important in the removal of excess urea from cells.Deficiency of CPS1 is an autosomal recessive disorder that causes hyperammonemia. CPS1 is a hepatocyte specific protein that localizes to the mitochondria of hepatocytes. It is a sensitive marker for distinguishing hepatocellular carcinomas (HCC) from other metastatic carcinomas as well as cholangio-carcinomas. HCC s occur primarily in the stomach, but they are also found in many other organs. CPS1 may also be a useful marker for intestinal metaplasia. Reportedly, strong expression of CPS1 correlates with smaller tumor size and longer patient survival. Occasionally, CPS1 is also found in gastric carcinomas as well as in a few other non-hepatic tumors.

UniProt: P31327

Pathways: Response to Growth Hormone Stimulus, Cellular Glucan Metabolic Process