CD72 anticorps

N° du produit ABIN7880345

Cet anticorps Souris Monoclonal détecte spécifiquement CD72 dans FACS et IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour CD72 anticorps (ABIN7880345)

Antigène: CD72 (CD72 Molecule (CD72))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD72 est non-conjugé

Application: Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: BU40

Détail du produit anti-CD72 anticorps

Fonction: CD72 Antibody

Purification: Protein G affinity chromatography

Immunogène: The HF B1 plasmacytoid cell line was used as the immunogen for this CD72 antibody.

Isotype: IgG2a, kappa

Information d'application

Indications d'application: Optimal dilution of the CD72 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the CD72 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur CD72

Antigène: CD72 (CD72 Molecule (CD72))

Autre désignation: CD72

Sujet: CD5 has been identified as a transmembrane glycoprotein that is expressed on 70 % of normal peripheral blood lymphocytes and on virtually all T lymphocytes in thymus and peripheral blood. Activation of T cells through the T cell receptor (TCR) results in tyrosine phosphorylation of CD5, and the absence of CD5 renders T cells hyper-responsive to TCR-mediated activation. CD5 associates with the TCR/CD3 chain, and with the Src family kinase, Lck p56. The C-type lectin superfamily member CD72 is a cell surface negative regulator of B cell activation from the pro-B through the mature B cell stage. CD72 serves as a receptor for CD5. The ability of lymphocytes to respond to antigenic or mitogenic stimulation utilizes both positive and negative regulatory proteins that influence the threshold for responsiveness. The human CD72 gene maps to chromosome 9p13.3 and encodes a transmembrane glycoprotein that contains an ITIM. Upon tyrosine phosphorylation, the CD72 ITIM recruits SH2-containing phosphatases such as SHP-1, resulting in downregulation of cell activation. CD72-/- mice contain hyperproliferative B cells.

UniProt: P21854

Pathways: BCR Signaling