Recombinant COBRA1 anticorps

N° du produit ABIN7880464

Cet anticorps anti-COBRA1 Monoclonal Lapin (Clone 32C80) (ABIN7880464) détecte spécifiquement COBRA1 dans WB, IHC, IF et ICC. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Recombinant COBRA1 anticorps (ABIN7880464)

Antigène: COBRA1 (Cofactor of BRCA1 (COBRA1))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp COBRA1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Clone: 32C80

Détail du produit anti-COBRA1 anticorps

Fonction: NELFB Antibody / Negative elongation factor B / COBRA1

Purification: Affinity-chromatography

Immunogène: A synthesized peptide derived from human NELFB was used as the immunogen for the NELFB antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the NELFB antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store the NELFB antibody at -20oC.

Détails sur COBRA1

Antigène: COBRA1 (Cofactor of BRCA1 (COBRA1))

Autre désignation: NELFB

Sujet: NELFB antibody targets negative elongation factor B, also known as COBRA1, a transcriptional regulator involved in RNA polymerase II pausing. NELFB functions as part of the NELF complex, which includes NELFA, NELFC/D, and NELFE subunits. This complex stabilizes paused RNA polymerase II at promoter-proximal regions, ensuring proper regulation of transcriptional elongation. By fine-tuning transcription, NELFB contributes to developmental programs and cellular stress responses.

Studies with NELFB antibody have implicated the protein in cancer biology and hormone signaling. COBRA1 was first identified as a BRCA1-associated factor, and disruption of NELFB function has been linked to breast cancer progression and altered estrogen receptor activity. Beyond cancer, NELFB also regulates genes involved in embryonic development and immune responses, making it a versatile factor for gene expression studies.

Validated antibody clones for NELFB detection work in assays such as western blot, chromatin immunoprecipitation, and immunohistochemistry. These reagents enable researchers to study promoter-proximal pausing, transcriptional control, and protein-protein interactions within the NELF complex. Clone validation ensures specificity for NELFB rather than closely related transcriptional regulators.

NSJ Bioreagents supplies this NELFB antibody for studies in transcription regulation, cancer pathways, and developmental biology. Alternate names include negative elongation factor B antibody, COBRA1 antibody, and cofactor of BRCA1 antibody.

UniProt: Q8WX92