Recombinant C1QA anticorps

N° du produit ABIN7880493

L’anticorps anti-C1QA Monoclonal Lapin est utilisé pour la détection de C1QA dans des échantillons de Humain et Rat. Il a été validé pour WB et IHC.

Aperçu rapide pour Recombinant C1QA anticorps (ABIN7880493)

Antigène: C1QA (Complement Component 1, Q Subcomponent, A Chain (C1QA))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp C1QA est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: 31C57

Détail du produit anti-C1QA anticorps

Fonction: C1QA Antibody / Complement component 1 subcomponent subunit A

Purification: Affinity-chromatography

Immunogène: A synthesized peptide derived from human C1QA was used as the immunogen for the C1QA antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the C1QA antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store the C1QA antibody at -20oC.

Détails sur C1QA

Antigène: C1QA (Complement Component 1, Q Subcomponent, A Chain (C1QA))

Autre désignation: C1QA

Sujet: C1QA antibody detects complement component 1 subcomponent subunit A, encoded by the C1QA gene. C1QA is one of three chains (A, B, and C) that assemble to form the C1q protein complex, a recognition unit of the classical complement pathway. C1q binds to antibodies or immune complexes, initiating complement activation and promoting clearance of pathogens and apoptotic cells. Through these roles, C1QA is central to innate immunity and host defense.

C1QA antibody is commonly used in immunology, inflammation, and autoimmune disease research. C1QA expression is highest in monocytes, macrophages, and dendritic cells. It functions as a pattern recognition receptor that bridges innate and adaptive immunity. By detecting C1QA, researchers can study activation of complement pathways and regulation of immune responses.

In western blot assays, C1QA antibody detects protein bands of expected size in immune cell extracts. Immunohistochemistry highlights strong expression in macrophages and tissue resident immune cells. Immunofluorescence enables visualization of C1QA in immune synapses and complement activation sites. ELISA supports quantification of circulating C1QA in biological samples.

Deficiency of C1QA is associated with autoimmune disorders such as systemic lupus erythematosus, underscoring its importance in self tolerance and immune clearance. Elevated expression of C1QA has been linked to chronic inflammation and neurodegenerative diseases, including Alzheimer disease, where complement activation contributes to pathology. By applying C1QA antibody, scientists can investigate how alterations in complement regulation affect health and disease.

C1QA antibody from NSJ Bioreagents offers reliable specificity for complement research. Its performance across methods ensures accurate detection of this key immune recognition protein.

UniProt: P02745

Pathways: Système du Complément