DRAP1 anticorps

N° du produit ABIN7880658

L’anticorps anti-DRAP1 Monoclonal Souris est utilisé pour la détection de DRAP1 dans des échantillons de Humain. Il a été validé pour WB, IF et FACS.

Aperçu rapide pour DRAP1 anticorps (ABIN7880658)

Antigène: DRAP1 (DR1-Associated Protein 1 (Negative Cofactor 2 Alpha) (DRAP1))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp DRAP1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Clone: PCRP-DRAP1-1A12

Détail du produit anti-DRAP1 anticorps

Fonction: NC2 alpha Antibody / DRAP1

Purification: Protein A/G affinity

Immunogène: Recombinant human protein was used as the immunogen for the NC2 alpha antibody.

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal dilution of the NC2 alpha antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the NC2 alpha antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur DRAP1

Antigène: DRAP1 (DR1-Associated Protein 1 (Negative Cofactor 2 Alpha) (DRAP1))

Autre désignation: NC2 alpha

Sujet: NC2 (negative cofactor 2) is a dimeric histone-fold complex that represses RNA polymerase II transcription through binding to TBP and inhibiting the transcription factors TFIIA and TFIIB. NC2 consists of two subunits, termed NC2a and NC2beta, and these subunits dimerize and bind to TBP-promoter complexes via histone fold domains of the H2A-H2B type. NC2 associates with promoters in a manner that correlates with transcriptional activity and with occupancy by basal transcription factors. NC2 binds directly to DNA, and the binding of NC2 to TBP-promoter complexes affects the conformation of DNA, and results in the inhibition of TFIIB.

UniProt: Q14919