Fc gamma RII (CD32) anticorps

N° du produit ABIN7880777

Cet anticorps Souris Monoclonal détecte spécifiquement Fc gamma RII dans FACS. Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Fc gamma RII (CD32) anticorps (ABIN7880777)

Antigène: Fc gamma RII (CD32)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Inconjugué

Application: Flow Cytometry (FACS)

Classe de qualité: Carrier-free

Clone: FCGR2A-479

Détail du produit

Fonction: CD32 Antibody (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogène: Recombinant human protein was used as the immunogen for the CD32 antibody.

Isotype: IgG2b, kappa

Information d'application

Indications d'application: Optimal dilution of the CD32 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the CD32 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détail du antigène

Antigène: Fc gamma RII (CD32)

Autre désignation: CD32

Sujet: This CD32 antibody binds most strongly to the IIa isoforms of CD32 (FcRII), a type 1 transmembrane glycoprotein that mediates several functions including phagocytosis, cytotoxicity, and immunomodulation as well as platelet aggregation. Three genes (A, B, and C) encode CD32 and at least 6 isoforms are generated via alternative mRNA splicing, i.e., IIa1, IIa2, IIb1, IIb2, IIb3 and IIc. Monocytes/macrophages, placental trophoblasts and endothelial cells express all isoforms. In addition, the IIb isoform is expressed by B cells, and the IIa isoform by platelets, granulocytes and, weakly, by B cells. NK cells and neutrophils express Isoform IIc. CD32 binds weakly to the Fc region of monomeric IgG but more strongly to IgG aggregates and immune complexes.

UniProt: P12318