FOXP1 anticorps

N° du produit ABIN7880816

Cet anticorps Lapin Polyclonal détecte spécifiquement FOXP1 dans WB et IHC (p). Il présente une réactivité avec des échantillons de Humain, Souris, Rat et Singe.

Aperçu rapide pour FOXP1 anticorps (ABIN7880816)

Antigène: FOXP1 (Forkhead Box P1 (FOXP1))

Reactivité: Humain, Souris, Rat, Singe

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FOXP1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Détail du produit anti-FOXP1 anticorps

Fonction: FOXP1 Antibody

Séquence: DFDHDRDYED EPVNEDME

Purification: Affinity purified

Immunogène: Amino acids DFDHDRDYEDEPVNEDME from the human protein were used as the immunogen for the FOXP1 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the FOXP1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the FOXP1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur FOXP1

Antigène: FOXP1 (Forkhead Box P1 (FOXP1))

Autre désignation: FOXP1

Sujet: FOXP1 (forkhead box P1) is a gene that is necessary for the proper development of the brain and lung in mammals. It is a member of the large FOX family of transcription factors. This gene belongs to subfamily P of the forkhead box(FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region(3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. It was shown that the embryonic stem cell(ESC)-specific isoform of FOXP1 stimulates the expression of transcription factor genes required for pluripotency, including OCT4, NANOG, NR5A2, and GDF3, while concomitantly repressing genes required for ESC differentiation. This isoform also promotes the maintenance of ESC pluripotency and contributes to efficient reprogramming of somatic cells into induced pluripotent stem cells. These results reveal a pivotal role for an Alternative splicing event in the regulation of pluripotency through the control of critical ESC-specific transcriptional programs(2).

UniProt: Q9H334

Pathways: Chromatin Binding, Regulation of Muscle Cell Differentiation, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response