Recombinant GAS2 anticorps

N° du produit ABIN7880928

L’anticorps anti-GAS2 Monoclonal Lapin est utilisé pour la détection de GAS2 dans des échantillons de Humain. Il a été validé pour WB et IHC.

Aperçu rapide pour Recombinant GAS2 anticorps (ABIN7880928)

Antigène: GAS2 (Growth Arrest-Specific 2 (GAS2))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp GAS2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: 31G23

Détail du produit anti-GAS2 anticorps

Fonction: GAS2 Antibody / Growth arrest specific protein 2

Purification: Affinity chromatography

Immunogène: A synthesized peptide derived from human GAS2 was used as the immunogen for the GAS2 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the GAS2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store the GAS2 antibody at -20oC.

Détails sur GAS2

Antigène: GAS2 (Growth Arrest-Specific 2 (GAS2))

Autre désignation: GAS2

Sujet: GAS2 antibody detects Growth arrest specific protein 2, encoded by the GAS2 gene. Growth arrest specific protein 2 is a cytoskeletal regulator that stabilizes microfilaments and microtubules. It is expressed during cell cycle arrest and differentiation, linking cytoskeletal dynamics to growth regulation. GAS2 antibody provides researchers with a useful reagent for studying cell growth, apoptosis, and cancer biology.

Growth arrest specific protein 2 contains actin binding domains and microtubule binding motifs that allow it to crosslink cytoskeletal components. Research using GAS2 antibody has demonstrated that it stabilizes actin filaments and microtubules during cell cycle arrest, contributing to maintenance of cell shape and integrity. By coordinating cytoskeletal structures, GAS2 helps control cell migration, adhesion, and survival.

In addition to cytoskeletal regulation, GAS2 is involved in apoptosis. Studies with GAS2 antibody have shown that it is cleaved by caspases during programmed cell death, producing fragments that promote cytoskeletal disassembly. This links GAS2 function to apoptotic morphology, including cell shrinkage and membrane blebbing. Dysregulation of GAS2 expression or cleavage contributes to abnormal cell survival in disease.

GAS2 has been studied in cancer, where its expression influences cell proliferation and migration. Research with GAS2 antibody has indicated that altered levels promote tumor progression by disrupting cytoskeletal control. Conversely, in some contexts GAS2 expression suppresses tumorigenesis by stabilizing growth arrest. This duality highlights its complex roles depending on cellular environment.

GAS2 antibody is used in western blotting, immunohistochemistry, and immunofluorescence. Western blotting detects full length and cleaved forms, immunohistochemistry shows distribution in growth arrested tissues, and immunofluorescence reveals colocalization with actin and tubulin. These applications make GAS2 antibody valuable in studies of cell cycle, cytoskeletal dynamics, and apoptosis.

By providing validated GAS2 antibody reagents, NSJ Bioreagents supports research into growth regulation, apoptosis, and cancer. Detection of Growth arrest specific protein 2 provides insight into how cytoskeletal stability intersects with cell fate decisions.

UniProt: O43903

Pathways: Caspase Cascade in Apoptosis