Recombinant GNAQ anticorps

N° du produit ABIN7880947

Cet anticorps anti-GNAQ Monoclonal Lapin (Clone 30G74) (ABIN7880947) détecte spécifiquement GNAQ dans WB, IHC, IF et ICC. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Recombinant GNAQ anticorps (ABIN7880947)

Antigène: GNAQ (Guanine Nucleotide Binding Protein (G Protein), Q Polypeptide (GNAQ))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp GNAQ est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Clone: 30G74

Détail du produit anti-GNAQ anticorps

Fonction: GNAQ Antibody / Guanine nucleotide binding protein Gq subunit alpha

Purification: Affinity chromatography

Immunogène: A synthesized peptide derived from human GNAQ was used as the immunogen for the GNAQ antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the GNAQ antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store the GNAQ antibody at -20oC.

Détails sur GNAQ

Antigène: GNAQ (Guanine Nucleotide Binding Protein (G Protein), Q Polypeptide (GNAQ))

Autre désignation: GNAQ

Sujet: GNAQ antibody detects Guanine nucleotide binding protein Gq subunit alpha, encoded by the GNAQ gene. This protein is a member of the heterotrimeric G protein alpha subunit family and couples receptors to downstream signaling cascades. Upon activation by G protein coupled receptors, GNAQ activates phospholipase C beta, leading to the production of inositol triphosphate and diacylglycerol. GNAQ antibody enables detailed study of this central signaling node and its contribution to cellular communication, growth, and differentiation.

Guanine nucleotide binding protein Gq subunit alpha plays a pivotal role in calcium signaling, activating pathways that regulate smooth muscle contraction, secretion, and gene expression. Dysregulation of GNAQ activity has been linked to developmental disorders, vascular anomalies, and cancers. Mutations in GNAQ are frequent in uveal melanoma and Sturge Weber syndrome, where they drive aberrant MAPK signaling and cell proliferation. Research using GNAQ antibody provides a means to detect altered protein levels and examine how mutant forms disrupt signaling dynamics.

Studies have also shown that GNAQ interacts with multiple effector pathways, including protein kinase C and Rho GTPases, extending its impact on cytoskeletal remodeling, migration, and survival. GNAQ antibody has been used to investigate signaling crosstalk in cardiovascular, neurological, and oncological contexts. Its function in coupling receptors to intracellular calcium release makes it indispensable for understanding receptor mediated physiology and pathology.

GNAQ antibody is employed in western blotting, immunohistochemistry, and immunofluorescence. Western blotting measures expression in tissues such as brain, heart, and smooth muscle. Immunohistochemistry visualizes localization in vascular endothelium and tumor samples. Immunofluorescence reveals distribution at the plasma membrane, consistent with its role as a receptor coupled G protein. Functional experiments have used GNAQ antibody to track expression changes following pharmacological inhibition of GPCR pathways.

By providing validated GNAQ antibody reagents, NSJ Bioreagents supports research in receptor signaling, cancer biology, and cardiovascular physiology. Guanine nucleotide binding protein Gq subunit alpha remains a vital component of GPCR signaling pathways, and detection with GNAQ antibody ensures reliable insights into its regulation and disease relevance.

UniProt: P50148

Pathways: Signalistation JAK/STAT, Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction