HES5 anticorps

N° du produit ABIN7880954

Cet anticorps Souris Monoclonal détecte spécifiquement HES5 dans IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour HES5 anticorps (ABIN7880954)

Antigène: HES5 (Hairy and Enhancer of Split 5 (HES5))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp HES5 est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: HES5-8035

Détail du produit anti-HES5 anticorps

Fonction: HES5 Antibody / BHLHB38

Purification: Protein G affinity

Immunogène: A recombinant partial protein from human HES5 protein was used as the immunogen for the HES5 antibody.

Isotype: IgG2, kappa

Information d'application

Indications d'application: Optimal dilution of the HES5 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Aliquot the HES5 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Détails sur HES5

Antigène: HES5 (Hairy and Enhancer of Split 5 (HES5))

Autre désignation: HES5

Sujet: The Drosophila Hairy and Enhancer of split genes encode basic helix-loop-helix (bHLH) transcriptional repressors that function in the Notch signaling pathway and control segmentation and neural development during embryogenesis. The mammalian homologues of Drosophila Hairy and Enhancer of split are the HES gene family members, HES1-6, which also encode bHLH transcriptional repressors that regulate myogenesis and neurogenesis. The HES family members form a complex with TLE, the mammalian homologue of Groucho, and this interaction is mediated by the carboxy terminal WRPW motif of the HES proteins. The HES/TLE complex functions by directly binding to DNA, instead of interfering with activator proteins. Most HES family members, including HES1 and HES5, preferentially bind to the N box (CACNAG) as opposed to the E box (CANNTG). HES2 binds to both N and E box sites, while HES6 does not bind DNA. Rather, HES6 inhibits HES1 activity, thereby promoting transcription. HES1 and HES2 are expressed in a variety of adult and embryonic tissues. HES3 is expressed exclusively in cerebellar Purkinje cells, and HES5 is found solely in the nervous system. HES6 is produced in brain as well as in the limb buds of developing embryos.

UniProt: Q5TA89

Pathways: Stem Cell Maintenance, Tube Formation