Human Papilloma Virus 18 E6 (HPV-18 E6) anticorps

N° du produit ABIN7881129

L’anticorps anti-Human Papilloma Virus 18 E6 Monoclonal Souris est utilisé pour la détection de Human Papilloma Virus 18 E6 dans des échantillons de Human Papillomavirus 18 (HPV-18). Il a été validé pour IHC (p).

Aperçu rapide pour Human Papilloma Virus 18 E6 (HPV-18 E6) anticorps (ABIN7881129)

Antigène: Human Papilloma Virus 18 E6 (HPV-18 E6)

Reactivité: Human Papillomavirus 18 (HPV-18)

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Inconjugué

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Classe de qualité: Carrier-free

Clone: HPV18-1297

Détail du produit

Fonction: HPV18 E6 Antibody (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogène: HPV18 E6-i²-galactosidase fusion protein was used as the immunogen for this HPV18 E6 antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the HPV18 E6 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Agent conservateur: Azide free

Stock: 4 °C,-20 °C

Stockage commentaire: Store the HPV18 E6 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détail du antigène

Antigène: Human Papilloma Virus 18 E6 (HPV-18 E6)

Autre désignation: HPV18 E6

Classe de substances: Viral Protein

Sujet: Human papilloma viruses (HPVs) can be classified as either high risk or low risk according to their association with cancer. HPV16 and HPV18 are the most common of the high risk group while HPV6 and HPV11 are among the low risk types. Approximately 90 % of cervical cancers contain HPV DNA of the high risk types. Mutational analysis has shown that the E6 and E7 genes of the high risk HPVs are necessary and sufficient for HPV transforming function. The specific interactions of the E6 and E7 proteins with p53 and pRB, respectively, correlate with HPV high and low risk classifications. The high risk HPV E7 proteins bind to pRB with a higher affinity than do the low risk HPV proteins, and only the high risk HPV E6 proteins form detectable complexes with p53 in vitro.