Human Papilloma Virus 18 E6 (HPV-18 E6) anticorps

N° du produit ABIN7881130

Cet anticorps anti-Human Papilloma Virus 18 E6 Monoclonal Souris (Clone HPV18-1297) (ABIN7881130) détecte spécifiquement Human Papilloma Virus 18 E6 dans IHC (p). L’anticorps est réactif avec des échantillons de Human Papillomavirus 18 (HPV-18).

Aperçu rapide pour Human Papilloma Virus 18 E6 (HPV-18 E6) anticorps (ABIN7881130)

Antigène: Human Papilloma Virus 18 E6 (HPV-18 E6)

Reactivité: Human Papillomavirus 18 (HPV-18)

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Inconjugué

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: HPV18-1297

Détail du produit

Fonction: HPV18 E6 Antibody

Purification: Protein G affinity chromatography

Immunogène: HPV18 E6-i²-galactosidase fusion protein was used as the immunogen for this HPV18 E6 antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: Optimal dilution of the HPV18 E6 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the HPV18 E6 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détail du antigène

Antigène: Human Papilloma Virus 18 E6 (HPV-18 E6)

Autre désignation: HPV18 E6

Classe de substances: Viral Protein

Sujet: Human papilloma viruses (HPVs) can be classified as either high risk or low risk according to their association with cancer. HPV16 and HPV18 are the most common of the high risk group while HPV6 and HPV11 are among the low risk types. Approximately 90 % of cervical cancers contain HPV DNA of the high risk types. Mutational analysis has shown that the E6 and E7 genes of the high risk HPVs are necessary and sufficient for HPV transforming function. The specific interactions of the E6 and E7 proteins with p53 and pRB, respectively, correlate with HPV high and low risk classifications. The high risk HPV E7 proteins bind to pRB with a higher affinity than do the low risk HPV proteins, and only the high risk HPV E6 proteins form detectable complexes with p53 in vitro.