Recombinant IL12B anticorps

N° du produit ABIN7881269

Cet anticorps anti-IL12B Monoclonal Lapin (Clone 31I13) (ABIN7881269) détecte spécifiquement IL12B dans WB, ICC, FACS et IF. L’anticorps est réactif avec des échantillons de Humain.

Aperçu rapide pour Recombinant IL12B anticorps (ABIN7881269)

Antigène: IL12B (Interleukin 12 beta (IL12B))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp IL12B est non-conjugé

Application: Western Blotting (WB), Immunocytochemistry (ICC), Flow Cytometry (FACS), Immunofluorescence (IF)

Clone: 31I13

Détail du produit anti-IL12B anticorps

Fonction: IL12B Antibody / Interleukin 12 beta / IL12 p40

Purification: Affinity-chromatography

Immunogène: A synthesized peptide derived from human IL12B was used as the immunogen for the IL12B antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the IL12B antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store the IL12B antibody at -20oC.

Détails sur IL12B

Antigène: IL12B (Interleukin 12 beta (IL12B))

Autre désignation: IL12B

Sujet: IL12B antibody detects interleukin 12 subunit beta, encoded by the IL12B gene. IL12B forms part of two heterodimeric cytokines, interleukin 12 and interleukin 23. In interleukin 12, IL12B pairs with the IL12A subunit to promote Th1 differentiation and interferon gamma production, supporting cellular immunity against intracellular pathogens. In interleukin 23, IL12B pairs with IL23A to stimulate Th17 responses and production of IL17, driving neutrophilic inflammation. Through these dual roles, IL12B is central to both protective immunity and inflammatory disease.

IL12B antibody is widely applied in immunology, inflammation, and translational medicine. By detecting IL12B, researchers can examine how immune signaling shapes host defense and pathology. Elevated IL12B expression contributes to autoimmune diseases such as psoriasis, Crohn disease, and multiple sclerosis. Conversely, defective IL12B leads to increased susceptibility to infection due to impaired Th1 responses.

ELISA quantifies IL12B in serum or culture supernatants. Western blot assays detect IL12B protein bands in activated immune cell lysates. Immunohistochemistry maps expression in lymphoid tissues, while immunofluorescence highlights secretion patterns in dendritic cells and macrophages. These diverse applications make IL12B antibody a versatile tool for immune research.

IL12B has therapeutic relevance as a target of monoclonal antibodies that block interleukin 12 and interleukin 23 signaling. Agents such as ustekinumab neutralize IL12B and provide clinical benefit in psoriasis and inflammatory bowel disease. By applying IL12B antibody, scientists can evaluate pathway activity and therapeutic responses in autoimmune and inflammatory disorders.

IL12B antibody from NSJ Bioreagents delivers strong specificity for analyzing cytokine biology. Its performance across multiple methods supports research into immune signaling and translational medicine.

UniProt: P29460

Pathways: Signalistation JAK/STAT, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation