Recombinant Iba1 anticorps

N° du produit ABIN7881326

Cet anticorps anti-Iba1 Monoclonal Lapin (Clone 31A74) (ABIN7881326) détecte spécifiquement Iba1 dans WB, IHC, ICC et IF. L’anticorps est réactif avec des échantillons de Humain, Rat et Souris.

Aperçu rapide pour Recombinant Iba1 anticorps (ABIN7881326)

Antigène: Iba1 (IBA1) (Ionized Calcium-binding Adapter Molecule 1 (IBA1))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp Iba1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)

Clone: 31A74

Détail du produit anti-Iba1 anticorps

Fonction: AIF1 Antibody / IBA1

Purification: Affinity-chromatography

Immunogène: A synthesized peptide derived from human Iba1 was used as the immunogen for the AIF1 antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the AIF1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store the AIF1 antibody at -20oC.

Détails sur Iba1

Antigène: Iba1 (IBA1) (Ionized Calcium-binding Adapter Molecule 1 (IBA1))

Autre désignation: AIF1

Sujet: IBA1 antibody detects allograft inflammatory factor 1 (AIF1), a calcium-binding protein expressed in microglia and macrophages. IBA1 participates in actin cytoskeleton remodeling, enabling immune cells to migrate and phagocytose effectively. In the central nervous system, it serves as a widely used microglial marker, allowing researchers to monitor immune responses within brain tissue. Its expression increases during neuroinflammation, making it valuable for studying disease-related activation states.

Applications of IBA1 antibody include research on Alzheimer's disease, Parkinson's disease, multiple sclerosis, and traumatic brain injury. Microglial activation visualized through IBA1 staining helps define the extent and nature of neuroimmune involvement in these conditions. Beyond neuroscience, AIF1 is also expressed in peripheral macrophages, where it regulates inflammatory pathways and vascular remodeling, linking it to atherosclerosis and transplant rejection models.

Antibodies against IBA1 are validated for immunohistochemistry, immunofluorescence, and western blot. These tools allow precise localization of microglia and provide insights into how immune cells interact with neurons and glia in health and disease. Clone-based products ensure high specificity with minimal background staining.

NSJ Bioreagents provides this IBA1 antibody for research applications in neuroscience, inflammation, and immunology. Alternate names include allograft inflammatory factor 1 antibody, ionized calcium-binding adapter molecule 1 antibody, and microglial marker antibody.

UniProt: P55008

Pathways: Smooth Muscle Cell Migration