MAT1A anticorps

N° du produit ABIN7881623

Cet anticorps anti-MAT1A Polyclonal Lapin (ABIN7881623) détecte spécifiquement MAT1A dans WB, FACS et IF. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour MAT1A anticorps (ABIN7881623)

Antigène: MAT1A (Methionine Adenosyltransferase I, alpha (MAT1A))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp MAT1A est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF)

Détail du produit anti-MAT1A anticorps

Fonction: MAT1A Antibody / Methionine adenosyltransferase 1

Séquence: DYQRVVRDTI KHIGYDD

Purification: Antigen affinity purified

Immunogène: Amino acids DYQRVVRDTIKHIGYDD were used as the immunogen for the MAT1A antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the MAT1A antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the MAT1A antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur MAT1A

Antigène: MAT1A (Methionine Adenosyltransferase I, alpha (MAT1A))

Autre désignation: Mat1a

Sujet: MAT1A antibody targets Methionine adenosyltransferase 1, encoded by the MAT1A gene. Methionine adenosyltransferase 1 is a cytosolic enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP, representing the primary source of cellular methyl donor in adult liver tissue. MAT1A is the dominant methionine adenosyltransferase isoform in hepatocytes and plays a central role in regulating cellular methylation capacity and metabolic homeostasis.

Functionally, Methionine adenosyltransferase 1 controls intracellular S-adenosylmethionine levels, thereby influencing DNA, RNA, protein, and lipid methylation reactions. Through regulation of methyl group availability, MAT1A indirectly modulates gene expression, chromatin structure, and signaling pathways linked to cellular growth and differentiation. A MAT1A antibody supports studies focused on methylation biology and liver-specific metabolic regulation.

MAT1A expression is highly enriched in adult liver and is markedly reduced or replaced by alternative isoforms in fetal liver and non-hepatic tissues. This tissue-specific expression pattern reflects its role in maintaining differentiated hepatocyte function and metabolic stability. Methionine adenosyltransferase 1 can associate with regulatory proteins and metabolic pathways that coordinate amino acid metabolism with epigenetic and transcriptional control mechanisms.

From a disease-relevance perspective, MAT1A has been extensively studied in liver disease and cancer biology. Reduced MAT1A expression or activity is associated with chronic liver disease, cirrhosis, and hepatocellular carcinoma, where disruption of S-adenosylmethionine homeostasis contributes to altered methylation and cellular transformation. MAT1A dysfunction has also been investigated in oxidative stress responses and metabolic imbalance, underscoring its importance in liver health and disease progression.

At the molecular level, Methionine adenosyltransferase 1 functions as a multimeric enzyme complex and contains conserved catalytic domains required for substrate binding and enzymatic activity. Regulatory mechanisms, including redox state and post-translational modification, can influence enzyme activity and apparent behavior in biochemical assays without altering primary sequence. MAT1A antibody reagents support research applications focused on liver metabolism, methylation-dependent signaling, and disease-associated metabolic dysregulation, with NSJ Bioreagents providing reagents intended for research use.

UniProt: Q00266

Pathways: Mitotic G1-G1/S Phases, M Phase, Ribonucleoside Biosynthetic Process, Methionine Biosynthetic Process