Spectrin beta Chain, Erythrocyte (SPTB) anticorps

N° du produit ABIN7882348

L’anticorps anti-Spectrin beta Chain, Erythrocyte Monoclonal Souris est utilisé pour la détection de Spectrin beta Chain, Erythrocyte dans des échantillons de Humain. Il a été validé pour WB, IF et IHC (p).

Aperçu rapide pour Spectrin beta Chain, Erythrocyte (SPTB) anticorps (ABIN7882348)

Antigène: Spectrin beta Chain, Erythrocyte (SPTB)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Inconjugué

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RG-26

Détail du produit

Fonction: SPTB Antibody / Spectrin beta

Purification: Protein G affinity chromatography

Immunogène: Red cell membranes were used as the immunogen for this Spectrin beta antibody.

Isotype: IgG2a, kappa

Information d'application

Indications d'application: Optimal dilution of the SPTB antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the SPTB antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détail du antigène

Antigène: Spectrin beta Chain, Erythrocyte (SPTB)

Autre désignation: SPTB

Sujet: Spectrin is a cytoskeletal protein that lines the intracellular side of the plasma membrane of many cell types in pentagonal or hexagonal arrangements, forming a scaffolding and playing an important role in maintenance of plasma membrane integrity and cytoskeletal structure. In certain types of brain injury such as diffuse axonal injury, spectrin is irreversibly cleaved by the proteolytic enzyme calpain, destroying the cytosketelon. Spectrin cleavage causes the membrane to form blebs and ultimately to be degraded, usually leading to cell death.

UniProt: P11277

Pathways: Regulation of Actin Filament Polymerization