Recombinant TARDBP anticorps

N° du produit ABIN7882428

Cet anticorps Lapin Monoclonal détecte spécifiquement TARDBP dans WB. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Recombinant TARDBP anticorps (ABIN7882428)

Antigène: TARDBP (TAR DNA Binding Protein (TARDBP))

Type d'anticorp: Recombinant Antibody

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Monoclonal

Conjugué: Cet anticorp TARDBP est non-conjugé

Application: Western Blotting (WB)

Clone: ABAB-20

Détail du produit anti-TARDBP anticorps

Fonction: TARDBP Antibody / TAR DNA binding protein 43 / TDP43

Purification: Affinity chromatography

Immunogène: A peptide sequence specific to TAR DNA binding protein 43 was used as the immunogen for the TARDBP antibody.

Isotype: IgG

Information d'application

Indications d'application: Optimal dilution of the TARDBP antibody should be determined by the researcher.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: After reconstitution, the TARDBP Antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Détails sur TARDBP

Antigène: TARDBP (TAR DNA Binding Protein (TARDBP))

Autre désignation: TARDBP

Sujet: TARDBP encodes TDP-43, a DNA/RNA-binding protein that regulates pre-mRNA splicing, transcript stability, and RNA transport. It shuttles between nucleus and cytoplasm and recognizes UG-rich elements through 2 RNA recognition motifs (RRM1/RRM2), while a low-complexity, glycine-rich C-terminus supports proteinâ€""protein and ribonucleoprotein assembly. Through these activities, TDP-43 coordinates RNA processing programs that influence neuronal function and broader cell biology.

TDP-43 participates in stress-responsive ribonucleoprotein remodeling and interacts with components of transcription, splicing, and translation pathways. Changes in localization, solubility, or post-translational status are widely monitored as readouts in studies of RNA metabolism, proteostasis, and cellular stress adaptation across model systems.

The TARDBP antibody enables specific detection of endogenous TDP-43 in applications such as western blot, immunofluorescence, immunohistochemistry, and immunoprecipitation. Researchers use the TARDBP antibody from NSJ Bioreagents to quantify total protein, assess nuclearâ€""cytoplasmic distribution, and evaluate biochemical fractionation outputs. With high specificity and consistent performance, the TARDBP antibody supports rigorous analysis of RNA-binding protein networks and RNA processing dynamics.

UniProt: Q13148

Pathways: Positive Regulation of Peptide Hormone Secretion