Thyroglobulin anticorps

N° du produit ABIN7882470

Cet anticorps Souris Monoclonal détecte spécifiquement Thyroglobulin dans IHC (p). Il présente une réactivité avec des échantillons de Humain.

Aperçu rapide pour Thyroglobulin anticorps (ABIN7882470)

Antigène: Thyroglobulin (TG)

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp Thyroglobulin est non-conjugé

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: SPM517

Détail du produit anti-Thyroglobulin anticorps

Fonction: Anti-TG Antibody

Purification: Protein G affinity chromatography

Immunogène: Human thyroid follicular cells were used as the immunogen for this anti-TG antibody.

Isotype: IgG1, kappa

Information d'application

Indications d'application: The optimal dilution of the anti-TG antibody for each application should be determined by the researcher.

1. Staining of formalin-fixed tissues requires boiling tissue sections in pH 9 10 mM Tris with 1 mM EDTA for 10-20 min followed by cooling at RT for 20 minutes.
2. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Prediluted in 1X PBS, 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide, *For IHC use only*

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store the anti-TG antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Détails sur Thyroglobulin

Antigène: Thyroglobulin (TG)

Autre désignation: TG

Sujet: Thyroglobulin (TG) is a 660 kDa dimeric pre-protein with mutiple glycosylation sites. It is produced by and processed within the thyroid gland to produce the hormone thyroxine and triiodothyronine. Prior to forming dimers, thyroglobulin monomers undergo conformational maturation in the endoplasmic reticulation. The vast majority of follicular carcinomas of the thyroid will give positive immunoreactivity for anti-thyroglobulin even though sometimes only focally. Poorly differentiated carcinomas of the thyroid are frequently anti-thyroglobulin negative. Adenocarcinomas of other-than-thyroid origin do not react with this antibody. This antibody is useful in identification of thyroid carcinoma of the papillary and follicular types. Presence of thyroglobulin in metastatic lesions establishes the thyroid origin of tumor. Anti-thyroglobulin, combined with anti-calcitonin, can identify medullary carcinomas of the thyroid. Furthermore, anti-thyroglobulin, combined with anti-TTF1, can be a reliable marker to differentiate between primary thyroid and lung neoplasms.

UniProt: P01266

Pathways: Thyroid Hormone Synthesis