CCKBR anticorps (Extracellular, N-Term)

N° du produit ABIN7884878

Cet anticorps anti-CCKBR Polyclonal Lapin (ABIN7884878) détecte spécifiquement CCKBR dans WB, IHC, FACS et LCI. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour CCKBR anticorps (Extracellular, N-Term) (ABIN7884878)

Antigène: CCKBR (Cholecystokinin B Receptor (CCKBR))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CCKBR est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Classe de qualité: Carrier-free

Détail du produit anti-CCKBR anticorps

Épitope: AA 39-53, Extracellular, N-Term

Fonction: A Rabbit Polyclonal Antibody to the Cholecystokinin B Receptor

Homologie: human - 13,Rat - 14,15 amino acid residues identical

Purification: Affinity purified on immobilized antigen.

Immunogène: CETPRIRGTGTRELE, corresponding to amino acid residues 39-53 of mouse Gastrin/cholecystokinin type B receptor

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: 5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: 1:100-1:200

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7235114)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur CCKBR

Antigène: CCKBR (Cholecystokinin B Receptor (CCKBR))

Autre désignation: Cholecystokinin B receptor

Sujet:

Synonyms: Cholecystokinin B receptor, Gastrin receptor, CCK2R, GASR

Description: Cholecystokinin B receptor (CCKBR), also known as the Gastrin receptor and CCKR2, belongs to the 7-transmembrane domain, G-protein coupled receptor (GPCR) superfamily, and is one of the two receptors that mediates the effects of the cholecystokinin (CCK) and gastrin peptides1,2.CCK and gastrin are related linear peptides that occur in different forms but share the last five C-terminal amino acid residues. CCK regulates several nutritional-related activities such as stimulation of pancreatic exocrine secretion or the regulation of intestinal transit, while gastrin's main function is the stimulation of gastric acid secretion1,2.Both CCKBR and the other CCK receptor (CCKAR or CCK1R) are coupled to a Gq/11 protein that activates phospholipase C (PLC) and leads to production of inositol 1,4,5-trisphosphate (InsP3), and intracellular Ca2+mobilization.CCKBR was originally identified in the brain (and hence its name, type B for Brain) where it is widely distributed, notably in the cerebral cortex and striatum. In the periphery, CCKBR is most notably expressed in acid secreting cells in the mucosa of the stomach. The tissue distribution of CCKBR corresponds to the proposed roles of the receptor which include anxiety, pain perception, gastric acid secretion, and growth and differentiation of the gastric mucosa1,2.

ID gène: 12426

UniProt: P56481

Pathways: Positive Regulation of Peptide Hormone Secretion, Feeding Behaviour