CNTF anticorps (C-Term)

N° du produit ABIN7884883

L’anticorps anti-CNTF Polyclonal Lapin est utilisé pour la détection de CNTF dans des échantillons de Humain, Rat et Souris. Il a été validé pour WB, IHC, IF et IC.

Aperçu rapide pour CNTF anticorps (C-Term) (ABIN7884883)

Antigène: CNTF (Ciliary Neurotrophic Factor (CNTF))

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp CNTF est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunochromatography (IC)

Classe de qualité: Carrier-free

Détail du produit anti-CNTF anticorps

Épitope: AA 164-177, C-Term

Fonction: A Rabbit Polyclonal Antibody to CNTF

Homologie: Rat,mouse - identical

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)ELSQWTVRSIHDLR, corresponding to amino acid residues 164-177 of human CNTF

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: 1:200

IHC: 1:200

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7235138)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur CNTF

Antigène: CNTF (Ciliary Neurotrophic Factor (CNTF))

Autre désignation: Ciliary neurotrophic factor

Sujet:

Synonyms: Ciliary neurotrophic factor

Description: CNTF is a polypeptide trophic factor, member of the alpha-helical cytokine superfamily1. It was initially purified from the chick eye on the basis of its ability to promote survival of E8 chick ciliary ganglion neurons in culture2. CNTF is synthesized by glia both in the CNS and PNS3 and it has been demonstrated that CNTF is ubiquitously distributed in neurons and glia throughout the rodent brain4. CNTF effects are mediated by a tripartite receptor complex consisting of two signal-transducing subunits (leukemia inhibitory factor receptor, gp130) and a CNTF-specific ligand-binding-subunit (CNTFR)5.CNTF can support the survival of many different cell populations within the PNS and the CNS6. in vitro, CNTF promotes proliferation and neuronal specifications in hippocampal neurons. in vivo, it supports the viability of non-primate motor neurons7, induces sprouting of cholinergic motor neurons8 and delays neural degeneration in genetic models of motor neuron disease9. In addition, it is involved in the development stage of astrocytes and oligodendocytes10.

ID gène: 1270

UniProt: P26441

Pathways: Signalistation JAK/STAT