DRD4 anticorps (3rd Intracellular Loop)

N° du produit ABIN7884920

Cet anticorps anti-DRD4 Polyclonal Lapin (ABIN7884920) détecte spécifiquement DRD4 dans WB. L’anticorps est réactif avec des échantillons de Souris et Rat.

Aperçu rapide pour DRD4 anticorps (3rd Intracellular Loop) (ABIN7884920)

Antigène: DRD4 (Dopamine Receptor D4 (DRD4))

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DRD4 est non-conjugé

Application: Western Blotting (WB)

Classe de qualité: Carrier-free

Détail du produit anti-DRD4 anticorps

Épitope: 3rd Intracellular Loop, AA 215-228

Fonction: A Rabbit Polyclonal Antibody to D4 Dopamine Receptor

Homologie: Mouse - identical, human - 9,14 amino acid residues identical

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)RRWEAARHTKLHSR, corresponding to amino acid residues 215-228 of rat DRD4 

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7235246)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur DRD4

Antigène: DRD4 (Dopamine Receptor D4 (DRD4))

Autre désignation: DRD4

Sujet:

Synonyms: DRD4, D4DR, D(2C) dopamine receptor

Description: The dopamine neurotransmitter belongs to the catecholamines and can therefore be further converted into adrenaline and noreadrenaline. Dopamine has various physiological roles, including learning and memory, motor output and endocrine regulation. It does so by binding and activating dopamine receptors which belong to the G-protein coupled receptor superfamily (GPCR)1.The D4 dopamine receptor (DRD4) belongs to the D2-like family as do D2 and D3 dopamine receptors. Like all GPCRs, it has seven transmembrane spanning membrane regions. Structure-wise, members of the family share high homology in the transmembrane domains and lower homology in the extracellular N-terminal and the intracellular C-terminal domains. Notably, the coding region of the 3rd intracellular loop of DRD4 is known to undergo extensive polymorphism2.Like many GPCRs, each dopamine receptor subtype can react with more than one G-protein giving rise to different signaling possibilities3. Whereas D2-like dopamine receptors are generally considered to couple to Gi, and therefore inhibit adenylyl cyclase, the signaling through DRD4 is complicated due to the polymorphisms in the 3rd intracellular loop. It seems that this region is important to G-coupling as different polyphormisms in the region influence the ability of DRD4 to couple to adenylyl cyclase and G-proteins4,5. D4 dopamine receptors also influence Ca2+ levels3,6. They could also interact with G-protein couple inwardly rectifying K+ channel to ultimately cause a decrease in the firing rate of neurons7.The distribution of DRD4 mostly includes the brain and is mainly found post-synaptically in dendritic shafts and spines of mammalian striatum8.

ID gène: 25432

UniProt: P30729

Pathways: cAMP Metabolic Process, Synaptic Membrane, Proton Transport, Photoperiodism, Negative Regulation of Transporter Activity