SH3G2 anticorps (Intracellular)

N° du produit ABIN7884928

L’anticorps anti-SH3G2 Polyclonal Lapin est utilisé pour la détection de SH3G2 dans des échantillons de Humain, Souris et Rat. Il a été validé pour WB et IHC.

Aperçu rapide pour SH3G2 anticorps (Intracellular) (ABIN7884928)

Antigène: SH3G2 (Endophilin-A1 (SH3G2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SH3G2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-SH3G2 anticorps

Épitope: AA 255-269, Intracellular

Fonction: A rabbit polyclonal antibody to Endophilin-A1

Homologie: Rat - identical. Human - 14 out of 15 amino acids identical

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)YQPKPRMSLEFATGD, corresponding to amino acid residues 255 - 269 of mouse SH3GL2

Isotype: IgG

Information d'application

Indications d'application: The optimal concentration should be determined by the user

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 25 μL, 50 μL or 0.2 mL double distilled water (DDW), depending on the sample size.

Concentration: 0.8 mg/mL

Buffer: PBS pH 7.4, 1 % BSA with 0.05 % sodium azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur SH3G2

Antigène: SH3G2 (Endophilin-A1 (SH3G2))

Autre désignation: SH3GL2

Sujet:

Synonyms: SH3 domain-containing GRB2-like protein 2, EEN-B1, SH3 domain protein 2A, SH3GL2

Description:

Endophilin-1 is a member of the Endophilin family, a group of proteins characterized by the presence of BAR (Bin/Amphiphysin/Rvs) and SH3 (Src Homology 3) domains.

The Endophilin family is primarily divided into two subfamilies. Endophilin A , that includes subunits A1, A2 and A3, is predominantly involved in membrane remodeling processes such clathrin-mediated and clathrin-independent endocytic pathways, especially in neurons. The Endophilin B subfamily includes subunits B1 and B2, and is more implicated in mitochondrial dynamics, autophagy and apoptosis.1,2

Endophilin-A1 is expressed almost exclusively in the brain, particularly in synaptic terminals in neurons, consistent with a neuronal specialization for membrane trafficking and synaptic function. It is essential for synaptic vesicle endocytosis, where it recruits and organizes proteins at sites of high membrane curvature to facilitate the formation and recycling of clathrin-coated vesicles at synaptic terminals. It is critical for dendritic spine morphogenesis, synaptic stabilization, and plasticity, supporting both excitatory and inhibitory synaptic organization.3,4

Changes in Endophilin-1 expression are linked to several neurodegenerative disease, most notably, Alzheimer's (AD) and Parkinson disease. Increased expression of Endophilin-1 has been observed in the brains of patients with AD and in transgenic mouse models of the disease.5,6

Endophilin-1 was identified as a Parkinson's disease risk locus and in addition, it was found to be upregulated in a mouse model of the disease.7,8

In summary, Endophilin-A1 not only serves as a compelling target for understanding synaptic biology but also holds promise as a biomarker and therapeutic candidate in neurodegenerative and neuropsychiatric diseases.

ID gène: 20404

UniProt: Q62420

Pathways: Neurotrophin Signaling Pathway, EGFR Downregulation