EPH Receptor A3 anticorps (Extracellular, N-Term)

N° du produit ABIN7884935

Cet anticorps anti-EPH Receptor A3 Polyclonal Lapin (ABIN7884935) détecte spécifiquement EPH Receptor A3 dans WB, IHC, IF, FACS et LCI. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour EPH Receptor A3 anticorps (Extracellular, N-Term) (ABIN7884935)

Antigène: EPH Receptor A3 (EPHA3)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EPH Receptor A3 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Classe de qualité: Carrier-free

Détail du produit anti-EPH Receptor A3 anticorps

Épitope: AA 488-500, Extracellular, N-Term

Fonction: A Rabbit Polyclonal Antibody to EphA3 Receptor

Homologie: Rat,mouse - identical

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)RARGTNVTISSLK, corresponding to amino acid residues 488-500 of human EphA3

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: 5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: 1:200

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7235282)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur EPH Receptor A3

Antigène: EPH Receptor A3 (EPHA3)

Autre désignation: Ephrin type-A receptor 3

Sujet:

Synonyms: Ephrin type-A receptor 3, EPH-like kinase 4, EK4, Tyrosine-protein kinase TYRO4

Description: Eph receptors are the largest family of receptor tyrosine kinases (RTKs). Based on sequence similarity and the type of ephrin ligands that they bind, they are classified into A and B sub-classes. EphA receptors bind ephrin-A ligand while EphB bind ephrin-B ligand.Eph receptors play an important role during embryonic development and are involved in several processes including cell adhesion, cell migration, and tissue boundary formation. Eph receptors are typically expressed at low levels in normal adult tissues1,2.EphA3 (Ephrin type-A receptor 3) structure includes a ligand-binding domain (LBD) at the N-terminus followed by a cysteine-rich region and two fibronectin III repeats. The receptor-binding domain of the ephrins is connected through a short linker segment to a GPI-anchor or a transmembrane segment3.EphA3 was first identified as a surface antigen on pre-B lymphoblastic leukemia cells. High EphA3 levels have been detected in a number of hematological cancers and solid tumors such as lung cancers, melanomas, gastric carcinoma, leukemia, in B and T cell malignancies and in glioblastoma multiforme. In addition, high levels of EphA3 are implicated in lymph node metastasis, advanced stages of colorectal cancer, and prostate cancer1,3,4.

ID gène: 2042

UniProt: P29320

Pathways: Signalisation RTK, Regulation of Cell Size