EPH Receptor A4 anticorps (Extracellular, N-Term)

N° du produit ABIN7884936

Cet anticorps Lapin Polyclonal détecte spécifiquement EPH Receptor A4 dans WB, FACS et LCI. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour EPH Receptor A4 anticorps (Extracellular, N-Term) (ABIN7884936)

Antigène: EPH Receptor A4 (EPHA4)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EPH Receptor A4 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Classe de qualité: Carrier-free

Détail du produit anti-EPH Receptor A4 anticorps

Épitope: AA 485-499, Extracellular, N-Term

Fonction: A Rabbit Polyclonal antibody to EphA4 (extracellular).

Homologie: Mouse,rat - identical

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)ERSYRIVRTAARNTD, corresponding to amino acid residues 485 - 499 of human EPHA4

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: 2.5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7235286)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur EPH Receptor A4

Antigène: EPH Receptor A4 (EPHA4)

Autre désignation: Ephrin Type-A Receptor 4

Sujet:

Synonyms: Ephrin Type-A Receptor 4, EPH-Like Kinase 8, EPHA4

Description: EphA4 is a member of the Eph receptor tyrosine kinase family.Eph receptors are subdivided into two subclasses, termed EphA and EphB, based on sequence similarity and their preference for binding a particular subclass of ephrins. The domain organization of Eph receptors contains a globular ligand binding domain (LBD), a cysteine-rich region, and two fibronectin type III domains (FN1 and FN2). It also contains a transmembrane (TM) helix, and an intracellular part consisting of a juxtamembrane (JM) region and a tyrosine kinase domain. Eph kinase activity is auto-inhibited through interaction with its own JM region, this auto inhibition is released by phosphorylation1.Interactions of Eph receptors with their ligands, ephrins, at cell-cell interfaces promote a variety of cellular responses, including repulsion, attraction and migration2.EphA4 is activated by all members of the ephrin-A ligand family and most members of the ephrin-B family1. Upon ligand binding it activates pathways that regulate the formation of the axon tract and cortical network as well as radial migration of cortical neurons in the cortex3.EphA4 is expressed in the neural ectoderm at embryonic day 8 and then in various cell types throughout the cortex during subsequent stages of neurodevelopment4, its major effect on cell-cell interfaces makes this receptor highly important for the study of cellular regeneration and various types of disease.

ID gène: 2043

Pathways: Signalisation RTK