EPH Receptor A6 anticorps (Extracellular, N-Term)

N° du produit ABIN7884939

Cet anticorps Lapin Polyclonal détecte spécifiquement EPH Receptor A6 dans WB, IHC, FACS et LCI. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour EPH Receptor A6 anticorps (Extracellular, N-Term) (ABIN7884939)

Antigène: EPH Receptor A6 (Epha6)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EPH Receptor A6 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Classe de qualité: Carrier-free

Détail du produit anti-EPH Receptor A6 anticorps

Épitope: AA 482-495, Extracellular, N-Term

Fonction: A Rabbit Polyclonal Antibody to EphA6 Receptor

Homologie: Mouse,human - identical

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)KEHEQLTYSSTRSK, corresponding to amino acid residues 482-495 of rat EphA6

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200-1:400

FC: 2.5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: 1:200

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7235290)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur EPH Receptor A6

Antigène: EPH Receptor A6 (Epha6)

Autre désignation: Ephrin type-A receptor 6

Sujet:

Synonyms: Ephrin type-A receptor 6, EPH receptor A6, EPH homology kinase 2, EHK-2

Description: EphA6 is an erythropoietin-producing hepatocellular (Eph) receptor that belongs to the tyrosine kinase receptor family. The Eph receptor family consists of 9 EphA receptors and 5 EphB receptors, which serve key roles in normal physiology, including cell migration, cell adhesion, cell proliferation and neuronal synaptic plasticity. These activities depend on the binding of their Eph receptor-interacting (ephrin) proteins, of which include 8 members. Compelling data has demonstrated that Eph receptors and ephrins affect tumor growth, invasiveness, angiogenesis and metastasis1. They are also involved in brain development, learning and memory2.EphA6 signaling pathways are inhibitory for developing axons and blocking these pathways enhances regeneration following spinal cord and brain injury, rendering EphA6 an appealing drug target3.Eph receptors contain an extracellular structure consisting of an ephrin binding domain, the juxtamembrane region connects the extracellular portion of the receptor to the intracellular kinase domain. Two Tyrosine residues on the juxtamembrane region mediate autophosphorylation and receptor dimerization mediates the formation of heterocomplexes that are required for signaling4.

ID gène: 29202

UniProt: P54758

Pathways: Signalisation RTK