EPH Receptor B4 anticorps (Extracellular, N-Term)

N° du produit ABIN7884941

Cet anticorps anti-EPH Receptor B4 Polyclonal Lapin (ABIN7884941) détecte spécifiquement EPH Receptor B4 dans WB, IHC, IF, FACS et LCI. L’anticorps est réactif avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour EPH Receptor B4 anticorps (Extracellular, N-Term) (ABIN7884941)

Antigène: EPH Receptor B4 (EPHB4)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp EPH Receptor B4 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Classe de qualité: Carrier-free

Détail du produit anti-EPH Receptor B4 anticorps

Épitope: AA 472-486, Extracellular, N-Term

Fonction: A Rabbit Polyclonal Antibody to EphB4 Receptor

Homologie: Rat,human - identical

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)HEKGAEGPSSVRFLK, corresponding to amino acid residues 472-486 of mouse EphB4

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: 2.5-5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: 1:100

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7235298)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur EPH Receptor B4

Antigène: EPH Receptor B4 (EPHB4)

Autre désignation: Ephrin type-B receptor 4

Sujet:

Synonyms: Ephrin type-B receptor 4, Eph receptor B4, Hepatoma transmembrane kinase, HTK

Description: EphB4 (Ephrin type-B receptor 4) is a member of the Eph family of receptor tyrosine kinases. Signaling pathways of these receptors play important roles in regulating numerous physiological processes during development including cell morphology, proliferation, migration and axonal guidance, dendritic spine formation and neural plasticity. Ephrins transduce bidirectional signals based on their distribution on the communicating cell surfaces. Eph receptors mediate forward signaling in one cell while ephrin ligands transmit reverse signaling in an adjacent cell1,2.Eph receptors consist of two large subfamilies: EphAs and EphBs that bind to either glycophosphatidylinositol (GPI)-anchored ephrin-A ligands or transmembrane ephrin-B ligands respectively. Each eph receptor may interact with multiple ligands, except for EPHB4, which only binds ephrin-B22.EPHB4 is expressed primarily during embryonic development in neural tissue and immature vasculature. Studies show that EphB4 is implicated in the growth of several epithelial tumors and is a promising target in cancer therapy. EphB4 signaling was found to promote tumor growth, invasiveness, chemoresistance and tumor angiogenesis3.

ID gène: 13846

UniProt: P54761

Pathways: Signalisation RTK