Ephrin A5 anticorps (Extracellular)

N° du produit ABIN7884944

Cet anticorps anti-Ephrin A5 Polyclonal Lapin (ABIN7884944) détecte spécifiquement Ephrin A5 dans WB, IHC et IF. L’anticorps est réactif avec des échantillons de Humain, Rat et Souris.

Aperçu rapide pour Ephrin A5 anticorps (Extracellular) (ABIN7884944)

Antigène: Ephrin A5 (EFNA5)

Reactivité: Humain, Rat, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Ephrin A5 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Classe de qualité: Carrier-free

Détail du produit anti-Ephrin A5 anticorps

Épitope: AA 172-186, Extracellular

Fonction: A Rabbit Polyclonal Antibody to Ephrin A5

Homologie: Mouse,rat - identical

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)DRVFDVNDKVENSLE, corresponding to amino acid residues 172-186 of human Ephrin-A5

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: 1:200

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7235310)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur Ephrin A5

Antigène: Ephrin A5 (EFNA5)

Autre désignation: EPH-related receptor tyrosine kinase ligand 7

Sujet:

Synonyms: EPH-related receptor tyrosine kinase ligand 7, LERK7, AL-1, EFNA5

Description: The Eph family of tyrosine kinase receptor signaling pathway is important for a variety of physiological processes during development including cell morphology, proliferation, migration and axonal guidance, dendritic spine formation and neural plasticity. Eph receptors mediate forward signaling in one cell while ephrin ligands transmit reverse signaling in an adjacent cell1-3.Eph receptors consist of two large subfamilies: EphA and EphB that bind to either glycophosphatidylinositol (GPI)-anchored ephrin-A ligands or transmembrane ephrin-B ligands respectively. Ephrin ligands are divided into ephrin-A (1 to 5) and ephrin-B (1 to 3)1,2.Ephrin-A5 is predominantly expressed in the quiescent anterior lens epithelial cells and is highly expressed in different layers of the cortex2,3.Studies show that mutations in ephrin-A5 are linked to congenital and age-related cataracts in humans and mice. Loss of ephrin-A5 causes abnormal localization of E-cadherin and β-catenin in anterior epithelial cells and epithelial-mesenchymal-transition2.

ID gène: 1946

UniProt: P52803

Pathways: Signalisation RTK