HRH1 anticorps (3rd Intracellular Loop)

N° du produit ABIN7885076

Cet anticorps anti-HRH1 Polyclonal Lapin (ABIN7885076) détecte spécifiquement HRH1 dans WB, IHC, IF, FACS et IC. L’anticorps est réactif avec des échantillons de Souris et Rat.

Aperçu rapide pour HRH1 anticorps (3rd Intracellular Loop) (ABIN7885076)

Antigène: HRH1 (Histamine Receptor H1 (HRH1))

Reactivité: Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HRH1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS), Immunochromatography (IC)

Classe de qualité: Carrier-free

Détail du produit anti-HRH1 anticorps

Épitope: 3rd Intracellular Loop

Fonction: A Rabbit Polyclonal Antibody to Histamine H1 Receptor

Homologie: Mouse - identical, human,dog - 13,14 amino acid residues identical

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)HSRQYVSGLHLNRE, corresponding to amino acids 396-409 of rat HRH1

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200-1:400

FC: The optimal concentration should be determined by the user

ICC: The optimal concentration should be determined by the user

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7235750)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur HRH1

Antigène: HRH1 (Histamine Receptor H1 (HRH1))

Autre désignation: H1R

Sujet:

Synonyms: H1R, HH1R

Description: Histamine (2-[4-imidazole]ethylamine) is a low-molecular-weight amine synthesized from L-histidine. It is produced by various cells throughout the body, including central nervous system neurons, gastric mucosa parietal cells, mast cells, basophils and lymphocytes. Histamine is a major biological mediator whose functions include, among many others, regulation of vascular smooth muscle, immune regulation, regulation of sleep-wake cycles and regulation of gastric acid secretion.1The biological effects of histamine are mediated through four receptors (H1-H4 receptors) all of which belong to the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily.H1 receptors couple to Gq/G11 proteins leading to phospholipase C activation, inositol phosphate production and calcium mobilization.1H1 receptors are expressed in many cell types including endothelial and smooth muscle cells where they mediate vasodilatation and increased vascular permeability effects. H1R is widely distributed through the brain where it mediates sleep-wake cycles and regulates cognitive functions. The receptor is expressed in several cell populations involved in the immune response, including T-cells and B-cells, monocytes and eosinophiles.2,3H1 anti-histamine compounds have been available for almost thirty years and are among the most commonly used medication for conditions such as allergic inflammation. In addition, H1 anti-histamines are also prescribed for the treatment of insomnia and analgesia.2,3

ID gène: 24448

UniProt: P31390

Pathways: Regulation of Carbohydrate Metabolic Process