HRH1 anticorps (Extracellular Loop)

N° du produit ABIN7885077

Cet anticorps Lapin Polyclonal détecte spécifiquement HRH1 dans WB, IHC, IF, FACS et LCI. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour HRH1 anticorps (Extracellular Loop) (ABIN7885077)

Antigène: HRH1 (Histamine Receptor H1 (HRH1))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp HRH1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS), Live Cell Imaging (LCI)

Classe de qualité: Carrier-free

Détail du produit anti-HRH1 anticorps

Épitope: AA 176-191, Extracellular Loop

Fonction: A Rabbit Polyclonal Antibody to Histamine H1 Receptor

Homologie: Mouse, human - 14,16 amino acid residues identical,rat - 15

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)REDK(S)ETDFYNVTWFK, corresponding to amino acid residues 176 - 191 of mouse H1 Histamine Receptor

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: 5 μg per reaction

ICC: The optimal concentration should be determined by the user

IHC: 1:300

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7235747)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur HRH1

Antigène: HRH1 (Histamine Receptor H1 (HRH1))

Autre désignation: Histamine Receptor H1

Sujet:

Synonyms: Histamine Receptor H1, H1R

Description: Histamine, acts via distinct histamine H1, H2, H3, and H4 receptors, and regulates various physiological and pathological processes. Hence the activity of Histamine receptors is very crucial. They are members of G-protein coupled receptors superfamily. Thus, have seven transmembrane domains, extracellular N-terminal tail and a cytoplasmic C-terminus1.H1 receptor is excitatory and couples to Gq-type proteins, activating a signaling cascade which eventually leads to an increased cellular concentration of Ca2+ 3.H1 receptor is implicated in type I hypersensitivity allergic reactions caused by numerous allergens1. An allergic reaction occurs when allergens activate mast cells that release histamine, the released histamine binds to H1R and this causes an activation of a cascade that leads to vasodilation and vascular hyper-permeability, resulting in allergic inflammation.H1R is expressed in various tissues throughout body, including the airway, vascular smooth muscle, and brain2. H1R expressed in the brain plays an important role in the regulation of sleep-arousal cycle and memory by binding histamine where it acts as a neurotransmitter1.

ID gène: 15465

UniProt: P70174

Pathways: Regulation of Carbohydrate Metabolic Process