Neuropilin 1 anticorps (Extracellular, N-Term)

N° du produit ABIN7885191

Cet anticorps Lapin Polyclonal détecte spécifiquement Neuropilin 1 dans WB, FACS, IF, IC et LCI. Il présente une réactivité avec des échantillons de Humain, Souris et Rat.

Aperçu rapide pour Neuropilin 1 anticorps (Extracellular, N-Term) (ABIN7885191)

Antigène: Neuropilin 1 (NRP1)

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Neuropilin 1 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunochromatography (IC), Live Cell Imaging (LCI)

Classe de qualité: Carrier-free

Détail du produit anti-Neuropilin 1 anticorps

Épitope: AA 502-514, Extracellular, N-Term

Fonction: A Rabbit Polyclonal Antibody to Neuropilin-1

Homologie: Rat,mouse - identical

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)GGKHRENKVFMRK, corresponding to amino acid residues 502-514 of human neuropilin-1

Isotype: IgG

Information d'application

Indications d'application:

WB: 1:200

FC: 2.5 μg per reaction

ICC: 1:25

IHC: The optimal concentration should be determined by the user

IP: The optimal concentration should be determined by the user

Commentaires:

Negative Control: (ABIN7236114)

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW)

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Agent conservateur: Without preservative

Stock: -20 °C

Stockage commentaire: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C

Détails sur Neuropilin 1

Antigène: Neuropilin 1 (NRP1)

Autre désignation: Vascular endothelial cell growth factor 165 receptor

Sujet:

Synonyms: Vascular endothelial cell growth factor 165 receptor, VEGF165R, CD304

Description: Neuropilins (NRPs) are co-receptors for class 3 semaphorins, polypeptides with key roles in axonal guidance, and for members of the VEGF (vascular endothelial growth factor) family of angiogenic cytokines.Neuropilin 1 (NRP1) is a transmembrane glycoprotein and comprises a large extracellular region containing multiple domains, a single transmembrane domain and a small cytoplasmic domain, also with a number of protein interacting domains.Class 3 semaphorins bind NRP1 (and NRP2) with different, and partially overlapping, specificities and affinities. Plexin A1 and Plexin A2 are the major signaling receptors for class 3 semaphorins, and complex with NRPs and semaphorins to form a holoreceptor essential for mediating effects of semaphorins on growth-cone collapse and axonal guidance in neurogenesis. The major VEGF-A signaling receptor, VEGF receptor 2, forms complexes with NRP1 and is important for optimal VEGFR2 signaling and function in endothelial cells.Targeted disruption of the NRP1 gene has demonstrated an essential dual role of these molecules in neurogenesis and cardiovascular development. NRP1-null mice die with a spectrum of cardiovascular and neuronal defects1.

ID gène: 8829

UniProt: O14786

Pathways: Regulation of Cell Size, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling, VEGFR1 Specific Signals